Trial reportStroke2008
Relationships between infarct growth, clinical outcome, and early recanalization in diffusion and perfusion imaging for understanding stroke evolution (DEFUSE).
Trial report in Stroke, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Failure of collateral blood flow is associated with infarct growth in ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Trial
- Dose-response and infusion duration of intra-arterial nimodipine in cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a single-center case series.Neuroradiology · 2025Observational
- Reversibility of diffuse magnetic resonance imaging following endovascular therapy in acute ischemic stroke: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization.Journal of the American Heart Association · 2024Article
- Characterizing Fast and Slow Progressors in Anterior Circulation Large Vessel Occlusion Strokes.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Brush sign and collateral supply as potential markers of large infarct growth after successful thrombectomy.European radiology · 2023Article
- Power of Hypoperfusion in Predicting Recurrent Transient Ischemic Attacks: Protocol of a Prospective Cohort Study.Frontiers in human neuroscience · 2021Article
- Infarct Growth despite Endovascular Thrombectomy Recanalization in Large Vessel Occlusive Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Penumbra volume predicts unfavorable outcome in patients with acute minor stroke or transient ischemic attack.Journal of the Chinese Medical Association : JCMA · 2020Article
- Risk factors of perfusion and diffusion abnormalities on MRI in hemispheric TIA: a case-control study.Annals of translational medicine · 2019Article
- Expression of S100B Protein in Ischemia/Reperfusion-Induced Brain Injury After Cyclosporine Therapy: A Biochemical Serum Marker with Prognostic Value?Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- History of Hypertension Is Associated With MR Hypoperfusion in Chinese Inpatients With DWI-Negative TIA.Frontiers in neurology · 2019Article
- Theophylline as an add-on to thrombolytic therapy in acute ischaemic stroke (TEA-Stroke): A randomized, double-blinded, placebo-controlled, two-centre phase II study.European stroke journal · 2016Article
- Utilization of Workflow Process Maps to Analyze Gaps in Critical Event Notification at a Large, Urban Hospital.Journal of digital imaging · 2016Article
- Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke.Frontiers in neurology · 2016Review
- Final infarct volume estimation on 1-week follow-up MR imaging is feasible and is dependent on recanalization status.NeuroImage. Clinical · 2015Article
- Recovery Potential After Acute Stroke.Frontiers in neurology · 2015Review
- Reperfusion therapies for acute ischemic stroke: an update.Current cardiology reviews · 2014Review
- Radiation doses of cerebral blood volume measurements using C-arm CT: A phantom study.AJNR. American journal of neuroradiology · 2014Article
- Data considerations in ischemic stroke trials.Neurological research · 2014Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
background and purposeThe purpose of this study was to determine the relationships between ischemic lesion growth, recanalization, and clinical response in stroke patients with and without a perfusion/diffusion mismatch.
methodsDEFUSE is an open label multicenter study in which 74 consecutive acute stroke patients were treated with intravenous tPA 3 to 6 hours after stroke onset. Magnetic resonance imaging (MRI) scans were obtained before, 3 to 6 hours after, and 30 days after treatment. Lesion growth was defined as the difference between the final infarct volume (30 day FLAIR) and the baseline diffusion lesion. Baseline MRI profiles were used to categorize 44 patients into Mismatch versus Absence of Mismatch subgroups. Early recanalization was assessed in 28 patients with an initial vessel lesion on magnetic resonance angiography. Infarct growth was compared based on whether a favorable clinical response (FCR) occurred and whether early recanalization was achieved.
resultsIn the Mismatch subgroup, FCR was associated with less infarct growth P=0.03 and early recanalization was predictive of both FCR (odds ratio: 22, P=0.047) and reduced infarct growth P=0.024. There was no significant relationship between recanalization, infarct growth, and clinical outcome in the Absence of Mismatch subgroup. A threshold of <7 cc of growth had the highest sensitivity and specificity for predicting a FCR in Mismatch patients (odds ratio: 65, P=0.015, sensitivity 82%, specificity 75%).
conclusionsIn contrast to Absence of Mismatch patients, significant associations between recanalization, reduced infarct growth, and favorable clinical response were documented in patients with a perfusion/diffusion mismatch who were treated with tPA within 3 to 6 hours after stroke onset. These findings support the Mismatch hypothesis but require validation in a larger study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.