ArticleBlood2008
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- CRISPR application in hematological disorders: from bench to bedside.Blood advances · 2026Review
- Article
- Dynamic Tracking of Native Precursors in Adult Mice.bioRxiv : the preprint server for biology · 2024Article
- Roles of USP1 in Ewing sarcoma.Genes & cancer · 2024Article
- Article
- Activation of Rho Family GTPases by Small Molecules.ACS chemical biology · 2018Article
- Reduced Cell Division Control Protein 42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells.Stem cells (Dayton, Ohio) · 2018Article
- Article
- Targeting Rho-GTPases in immune cell migration and inflammation.British journal of pharmacology · 2014Review
- Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress.Antioxidants & redox signaling · 2014Article
- Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche.Journal of biomedical science · 2013Article
- The PI3K/Akt1 pathway enhances steady-state levels of FANCL.Molecular biology of the cell · 2013Article
- Article
- Impaired function of Fanconi anemia type C-deficient macrophages.Journal of leukocyte biology · 2012Article
- Cdc42 in oncogenic transformation, invasion, and tumorigenesis.Cellular signalling · 2011Review
- Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector.Gene therapy · 2010Article
- Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.Stem cells (Dayton, Ohio) · 2010Article
- Rho GTPases in hematopoiesis and hemopathies.Blood · 2010Review
- Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer.Anemia · 2010Article
- Genetic correction of hematopoiesis in Fanconi anemia: the case for a non-HSC-autonomous defect.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
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11 authors.
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Abstract
Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mutations in FA complementation group A (FA-A), we show that when transplanted into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) recipient mice, FA-A BM cells exhibited impaired homing activity. FA-A cells also showed defects in both cell-cell and cell-matrix adhesion. Complementation of FA-A deficiency by reexpression of FANCA readily restored adhesion of FA-A cells. A significant decrease in the activity of the Rho GTPase Cdc42 was found associated with these defective functions in patient-derived cells, and expression of a constitutively active Cdc42 mutant was able to rescue the adhesion defect of FA-A cells. These results provide the first evidence that FA proteins influence human BM progenitor homing and adhesion via the small GTPase Cdc42-regulated signaling pathway.
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