ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance.Frontiers in systems neuroscience · 2022Article
- Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: A novel fluorescence imaging method.Autonomic neuroscience : basic & clinical · 2020Article
- Spatial Inhomogeneity of Cardiac Norepinephrine Transport Protein and Meta-[Molecular imaging and biology · 2019Article
- Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension.Autonomic neuroscience : basic & clinical · 2013Article
- Assessment of cardiac autonomic neuronal function using PET imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia.Cardiovascular diabetology · 2011Article
- Expression and distribution of dopamine transporter in cardiac tissues of the guinea pig.Neurochemical research · 2011Article
- Foetal nicotine exposure causes PKCε gene repression by promoter methylation in rat hearts.Cardiovascular research · 2011Article
- Expressions of cardiac sympathetic norepinephrine transporter and beta1-adrenergic receptor decreased in aged rats.Journal of Zhejiang University. Science. B · 2009Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The cardiac neuronal norepinephrine (NE) transporter (NET) in sympathetic neurons is responsible for uptake of released NE from the neuroeffector junction. The purpose of this study was to assess the chamber distribution of cardiac NET protein measured using [(3)H]nisoxetine binding in rat heart membranes and to correlate NE content to NET amount. In whole mounts of atria, NET was colocalized in nerve fibers with tyrosine hydroxylase (TH) immunoreactivity. NE content expressed as micrograms NE per gram tissue was lowest in the ventricles; however, NET binding was significantly higher in the left ventricle than the right ventricle and atria (P < 0.05), resulting in a significant negative correlation (r(2) = 0.922; P < 0.05) of NET to NE content. The neurotoxin 6-hydroxydopamine, an NET substrate, reduced NE content more in the ventricles than the atria, demonstrating functional significance of high ventricular NET binding. In summary, there is a ventricular predominance of NET binding that corresponds to a high NE reuptake capacity in the ventricles, yet negatively correlates to tissue NE content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.