ArticleJournal of periodontal research2008
Differential gender effects of a reduced-calorie diet on systemic inflammatory and immune parameters in nonhuman primates.
Article in Journal of periodontal research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Could dietary restrictions affect periodontal disease? A systematic review.Clinical oral investigations · 2023Pooled it
- Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial.Journal of clinical periodontology · 2025Trial
- Characteristics of the Health-Associated Oral Microbiome in Young Nonhuman Primates.Molecular oral microbiology · 2026Article
- Sex effects on early life features of the gingival transcriptome.Frontiers in dental medicine · 2025Article
- Sex and Age Effects on Healthy Gingival Transcriptomic Patterns.Journal of dental research · 2023Article
- Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease-A Suggested Preventive Strategy to Reduce the Public Health Burden.International journal of environmental research and public health · 2022Review
- Article
- Identification and validation of a classifier based on hub aging-related genes and aging subtypes correlation with immune microenvironment for periodontitis.Frontiers in immunology · 2022Article
- Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.Frontiers in oral health · 2022Article
- Gingival transcriptomics of follicular T cell footprints in progressing periodontitis.Clinical and experimental immunology · 2021Article
- Transcriptomic phases of periodontitis lesions using the nonhuman primate model.Scientific reports · 2021Article
- Oral microbiome interactions with gingival gene expression patterns for apoptosis, autophagy and hypoxia pathways in progressing periodontitis.Immunology · 2021Article
- Oral Microbiome and Gingival Gene Expression of Inflammatory Biomolecules With Aging and Periodontitis.Frontiers in oral health · 2021Article
- Oral Microbiome and Gingival Tissue Apoptosis and Autophagy Transcriptomics.Frontiers in immunology · 2020Article
- Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span.Infection and immunity · 2019Article
- Ageing effects on humoral immune responses in chronic periodontitis.Journal of clinical periodontology · 2018Article
- Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis.Journal of clinical periodontology · 2014Article
- Periodontitis in pregnant baboons: systemic inflammation and adaptive immune responses and pregnancy outcomes in a baboon model.Journal of periodontal research · 2014Article
- Will calorie restriction work in humans?Aging · 2013Article
- Caloric restriction and chronic inflammatory diseases.Oral diseases · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveDietary manipulation, including caloric restriction, has been shown to impact host response capabilities significantly, particularly in association with aging. This investigation compared systemic inflammatory and immune-response molecules in rhesus monkeys (Macaca mulatta). MATERIAL AND
methodsMonkeys on continuous long-term calorie-restricted diets and a matched group of animals on a control ad libitum diet, were examined for systemic response profiles including the effects of both gender and aging.
resultsThe results demonstrated that haptoglobin and alpha1-antiglycoprotein levels were elevated in the serum of male monkeys. Serum IgG responses to Campylobacter rectus, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were significantly elevated in female monkeys. While only the antibody to Fusobacterium nucleatum was significantly affected by the calorie-restricted diet in female monkeys, antibody levels to Prevotella intermedia, C. rectus and Treponema denticola demonstrated a similar trend.
conclusionIn this investigation, only certain serum antibody levels were influenced by the age of male animals, which was seemingly related to increasing clinical disease in this gender. More generally, analytes were modulated by gender and/or diet in this oral model system of mucosal microbial challenge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.