ReviewNeurochemical research2008
Astrocyte and neuron intone through glutamate.
Review in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies.The journal of headache and pain · 2020Pooled it
- Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review.European journal of neurology · 2026Review
- Glutamate, a Key for Astrocytes to Participate in Brain Function and Diseases.Neurochemical research · 2025Review
- Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture.Neurochemical research · 2022Article
- D-2-Hydroxyglutarate in Glioma Biology.Cells · 2021Review
- Malignant invasion of the central nervous system: the hidden face of a poorly understood outcome of prostate cancer.World journal of urology · 2018Review
- Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.Neurotoxicity research · 2015Article
- The Impact of Neuroimmune Alterations in Autism Spectrum Disorder.Frontiers in psychiatry · 2015Review
- Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.Autophagy · 2014Article
- Regulation and dysregulation of astrocyte activation and implications in tumor formation.Cellular and molecular life sciences : CMLS · 2013Review
- Glutamate-dependent translational control in cultured Bergmann glia cells: eIF2α phosphorylation.Neurochemical research · 2013Article
- Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects.Neurochemical research · 2013Article
- Posterior insular molecular changes in myofascial pain.Journal of dental research · 2012Article
- Emerging role of glial cells in the control of body weight.Molecular metabolism · 2012Article
- Astrocytes express N-methyl-D-aspartate receptor subunits in development, ischemia and post-ischemia.Neurochemical research · 2010Article
- Hypoxic-ischemic encephalopathy in the term infant.Clinics in perinatology · 2009Review
- Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel.The Journal of physiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unexpected finding of astrocytes to release glutamate as gliotransmitter challenges the traditional concepts on astrocyte being "passive" in CNS communications. Glutamate is the major excitatory transmitter in transferring information between neurons, but is now also known to activate astrocyte through transporters and receptors. Together with the sensitive swelling response, astrocytes could respond directly to glutamate and neuronal activity. Other new functions of astrocytes include modulation of synaptic plasticity and cerebral blood flow (CBF). The classic glutamate deplenishment through glutamine synthesis and CO(2) production does not account for the total glutamate internalized into astrocytes. This leads us to speculate there are many hidden functions of glutamate in neurons and astrocytes waiting to be discovered. In this review, we attempted to reexamine some of these new and older functions of glutamate and to reevaluate the roles of glutamate intoning these two cell types.
Indexed as
Identifiers
18563562What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.