ArticleJournal of computational neuroscience2009
Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron.
Article in Journal of computational neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Computer models predict differential dendritic vulnerability with ischemia and spreading depression.PLoS computational biology · 2026Article
- Computer models predict differential dendritic vulnerability with ischemia and spreading depression.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms of the negative potential associated with Leão's spreading depolarization: A history of brain electrogenesis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Dynamics of a neuron-glia system: the occurrence of seizures and the influence of electroconvulsive stimuli : A mathematical and numerical study.Journal of computational neuroscience · 2020Article
- Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback.Neural plasticity · 2020Article
- Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.Frontiers in cellular neuroscience · 2015Article
- Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Ion concentration dynamics as a mechanism for neuronal bursting.Journal of biological physics · 2011Article
- Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron.Journal of computational neuroscience · 2009Article
- Computer simulations of neuron-glia interactions mediated by ion flux.Journal of computational neuroscience · 2008Article
- Seizure-like afterdischarges simulated in a model neuron.Journal of computational neuroscience · 2007Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As described by others, an extracellular calcium-sensitive non-selective cation channel ([Ca(2+)](o)-sensitive NSCC) of central neurons opens when extracellular calcium level decreases. An other non-selective current is activated by rising intracellular calcium ([Ca(2+)]( i )). The [Ca(2+)](o)-sensitive NSCC is not dependent on voltage and while it is permeable by monovalent cations, it is blocked by divalent cations. We tested the hypothesis that activation of this channel can promote seizures and spreading depression (SD). We used a computer model of a neuron surrounded by interstitial space and enveloped in a glia-endothelial "buffer" system. Na(+), K(+), Ca(2+) and Cl(-) concentrations, ion fluxes and osmotically driven volume changes were computed. Conventional ion channels and the NSCC were incorporated in the neuron membrane. Activation of NSCC conductance caused the appearance of paroxysmal afterdischarges (ADs) at parameter settings that did not produce AD in the absence of NSCC. The duration of the AD depended on the amplitude of the NSCC. Similarly, NSCC also enabled the generation of SD. We conclude that NSCC can contribute to the generation of epileptiform events and to spreading depression.
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