ArticleMammalian genome : official journal of the International Mammalian Genome Society2008
The genomic determinants of alcohol preference in mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Meta-Analysis of Gene Expression Patterns in Animal Models of Prenatal Alcohol Exposure Suggests Role for Protein Synthesis Inhibition and Chromatin Remodeling.Alcoholism, clinical and experimental research · 2016Pooled it
- The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption.The FEBS journal · 2015Pooled it
- Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Modulation of neuronal excitability by binge alcohol drinking.Frontiers in molecular neuroscience · 2023Review
- Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice.Brain research · 2022Article
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- Development of a tissue augmented Bayesian model for expression quantitative trait loci analysis.Mathematical biosciences and engineering : MBE · 2019Article
- Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.Genes, brain, and behavior · 2019Article
- Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys.Frontiers in molecular neuroscience · 2019Article
- Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse.BMC genomics · 2018Article
- Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.Journal of neuroinflammation · 2018Article
- Altered gene expression in early postnatal monoamine oxidase A knockout mice.Brain research · 2017Article
- The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons.Frontiers in cellular neuroscience · 2017Article
- The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies.Pharmacogenomics · 2016Review
- Effects of embryonic ethanol exposure at low doses on neuronal development, voluntary ethanol consumption and related behaviors in larval and adult zebrafish: Role of hypothalamic orexigenic peptides.Behavioural brain research · 2016Article
- Applying the new genomics to alcohol dependence.Alcohol (Fayetteville, N.Y.) · 2015Review
- Transcriptome organization for chronic alcohol abuse in human brain.Molecular psychiatry · 2015Article
- Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Advances in Medications and Tailoring Treatment for Alcohol Use Disorder.Alcohol research : current reviews · 2015Review
- Identification of gene expression profile in the rat brain resulting from acute alcohol intoxication.Molecular biology reports · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Searches for the identity of genes that influence the levels of alcohol consumption by humans and other animals have often been driven by presupposition of the importance of particular gene products in determining positively or negatively reinforcing effects of ethanol. We have taken an unbiased approach and performed a meta-analysis across three types of mouse populations to correlate brain gene expression with levels of alcohol intake. Our studies, using filtering procedures based on QTL analysis, produced a list of eight candidate genes with highly heritable expression, which could explain a significant amount of the variance in alcohol preference in mice. Using the Allen Brain Atlas for gene expression, we noted that the candidate genes' expression was localized to the olfactory and limbic areas as well as to the orbitofrontal cortex. Informatics techniques and pathway analysis illustrated the role of the candidate genes in neuronal migration, differentiation, and synaptic remodeling. The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.