ArticleEuropean child & adolescent psychiatry2009
Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder.
Article in European child & adolescent psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- ADHD and the DRD4 exon III 7-repeat polymorphism: an international meta-analysis.Social cognitive and affective neuroscience · 2010Pooled it
- Review
- A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD).Frontiers in human neuroscience · 2019Review
- Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018Review
- Low dopamine function in attention deficit/hyperactivity disorder: should genotyping signify early diagnosis in children?Postgraduate medicine · 2014Review
- The genetics of attention deficit/hyperactivity disorder in adults, a review.Molecular psychiatry · 2012Review
- Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder.Genes, brain, and behavior · 2011Article
- Attention-deficit/hyperactivity disorder in perspective.European child & adolescent psychiatry · 2010Article
- Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD).Neuropsychiatric disease and treatment · 2010Article
- Molecular genetics of attention-deficit/hyperactivity disorder: an overview.European child & adolescent psychiatry · 2010Review
- From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders.European child & adolescent psychiatry · 2010Review
- Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder.Psychiatry research · 2009Article
- Advances in genetic studies of attention-deficit/hyperactivity disorder.Current psychiatry reports · 2009Review
- The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene-environment interaction.Journal of child psychology and psychiatry, and allied disciplines · 2008Article
- An Overview on the Genetics of ADHD.Xin li xue bao. Acta psychologica Sinica · 2008Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveThe developmental trajectory of attention-deficit hyperactivity disorder (ADHD) is variable. Utilizing a longitudinally assessed sample, we investigated the contribution of susceptibility gene variants, previously implicated through pooled or meta-analyses, to the developmental course of Attention-Deficit Hyperactivity Disorder over time.
methods151 children (aged 6-12) who met diagnostic criteria for ADHD were assessed using research diagnostic interviews during childhood and 5 years later in adolescence. Severity was defined as total number of ADHD symptoms at baseline and reassessment. Association with variants at DRD4, DRD5, and the dopamine transporter gene, DAT was analyzed using linear regression.
resultsAs expected, affected individuals showed a decline in ADHD severity over time. The DRD4 48 bp VNTR 7-repeat and DRD5 CA(n) microsatellite marker 148 bp risk alleles were associated with persistent ADHD. Those possessing the DRD4 7 repeat risk allele showed less of a decline in severity at reassessment than those without the risk allele.
conclusionsThose carrying the DRD4 7 risk allele showed greater symptom severity at follow-up and less ADHD reduction over time. These findings support the hypothesis that some susceptibility genes for ADHD also influence its developmental course.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.