Trial reportEuropean journal of applied physiology2008
Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise.
Trial report in European journal of applied physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Pooled it
- Are There Benefits from the Use of Fish Oil Supplements in Athletes? A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2018Pooled it
- Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials.American journal of hypertension · 2014Pooled it
- Muscular endurance and muscle metabolic responses to 8 weeks of omega-3 polyunsaturated fatty acids supplementation.Physiological reports · 2020Trial
- Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2012Trial
- Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.Journal of clinical medicine research · 2022Article
- Exercise Training Combined with Calanus Oil Supplementation Improves the Central Cardiodynamic Function in Older Women.Nutrients · 2021Article
- Correlation between invasive and noninvasive blood pressure measurements in severely burned children.Burns : journal of the International Society for Burn Injuries · 2018Article
- Marine bioactives and potential application in sports.Marine drugs · 2014Article
- DHA- Rich Fish Oil Improves Complex Reaction Time in Female Elite Soccer Players.Journal of sports science & medicine · 2011Article
- Resolvins and protectins: mediating solutions to inflammation.British journal of pharmacology · 2009Review
- Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.The Journal of nutrition · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects on cardiovascular function. We tested the hypotheses that dietary supplementation with DHA (2 g/day) + EPA (3 g/day) enhances increases in stroke volume (SV) and cardiac output (CO) and decreases in systemic vascular resistance (SVR) during dynamic exercise. Healthy subjects received DHA + EPA (eight men, four women) or safflower oil (six men, three women) for 6 weeks. Both groups performed 20 min of bicycle exercise (10 min each at a low and moderate work intensity) before and after DHA + EPA or safflower oil treatment. Mean arterial pressure (MAP), heart rate (HR), SV, CO, and SVR were assessed before exercise and during both workloads. HR was unaffected by DHA + EPA and MAP was reduced, but only at rest (88 +/- 5 vs. 83 +/- 4 mm Hg). DHA + EPA augmented increases in SV (14.1 +/- 6.3 vs. 32.3 +/- 8.7 ml) and CO (8.5 +/- 1.0 vs. 10.3 +/- 1.2 L/min) and tended to attenuate decreases in SVR (-7.0 +/- 0.6 vs. -10.1 +/- 1.6 mm Hg L(-1) min(-1)) during the moderate workload. Safflower oil treatment had no effects on MAP, HR, SV, CO or SVR at rest or during exercise. DHA + EPA-induced increases in SV and CO imply that dietary supplementation with these fatty acids can increase oxygen delivery during exercise, which may have beneficial clinical implications for individuals with cardiovascular disease and reduced exercise tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.