ArticleEuropean journal of clinical pharmacology2008
Antibiotic drug use of children in the Netherlands from 1999 till 2005.
Article in European journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Knowledge, attitudes, and practices of parents toward antibiotic use in children attending public hospitals in Mogadishu, Somalia.Tropical medicine and health · 2026Article
- Integrative evidence-informed management of feverish illnesses in childhood-outcomes of the public FeverFriend prospective app registry.Frontiers in public health · 2026Article
- Article
- Prevalence of use of on-label and off-label psychotropics in the Greek pediatric population.Frontiers in pharmacology · 2024Article
- Antibiotic prescribing trends in a pediatric population in Lithuania in 2003-2012: Observational study.Medicine · 2019Observational
- Trends in paediatric inpatient antibiotic therapy in a secondary care setting.European journal of pediatrics · 2018Article
- Cross-border comparison of antibiotic prescriptions among children and adolescents between the north of the Netherlands and the north-west of Germany.Antimicrobial resistance and infection control · 2016Article
- Antibiotic prescribing trends in an omani paediatric population.Sultan Qaboos University medical journal · 2014Article
- Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study.BMC pediatrics · 2014Article
- Knowledge, attitudes, and practices of parents in rural China on the use of antibiotics in children: a cross-sectional study.BMC infectious diseases · 2014Article
- Antibiotic Use in Children with Acute Respiratory or Ear Infections: Prospective Observational Comparison of Anthroposophic and Conventional Treatment under Routine Primary Care Conditions.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Effect of a sugar-free pediatric antibiotic on primary tooth enamel hardness when exposed to different sucrose exposure conditions in situ.Clinical oral investigations · 2014Article
- Article
- Systemic antibiotic use among children and adolescents in Germany: a population-based study.European journal of pediatrics · 2013Article
- Prescription drug dispensing profiles for one million children: a population-based analysis.European journal of clinical pharmacology · 2013Article
- Article
- Determinants of the drug utilization profile in the paediatric population in Italy's Lombardy Region.British journal of clinical pharmacology · 2009Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAntibiotics are the most commonly prescribed drugs used by children. Excessive and irrational use of antibiotic drugs is a world-wide concern. We performed a drug utilization study describing the patterns of antibiotic use in children aged 0-19 years between 1999 and 2005 in the Netherlands.
methodsWe used IADB.nl, a database with pharmacy drug dispensing data covering a population of 500,000 people and investigated all prescriptions of oral antibiotic drugs (ATC J01) for children <or=19 years between 1999 and 2005.
resultsThe total number of antibiotic prescriptions per 1000 children per year ranged from 282 in 2004 to 307 in 2001 and did not change between years during the study period in a clinically relevant way. The prevalence of receiving at least one prescription varied between 17.8% in 2004 and 19.3% in 2001. Amoxicillin was the most frequently prescribed drug (46.4% of all antibiotic prescriptions in 1999 and 43.2% in 2005). Between 1999 and 2005 there was a shift from the small-spectrum phenethicillin, a penicillin preparation [ratio 2005/1999 0.76; 95% confidence interval (CI) 0.72-0.81], to amoxicillin/clavulanic acid (ratio 2005/1999 1.70; 95% CI 1.61-1.79) and from the old macrolide erythromycin (ratio 2005/1999 0.35; 95% CI 0.32-0.39) to the new macrolide antibiotic azithromycin (ratio 2005/1999 1.78; 95% CI 1.65-1.92).
conclusionThe use of antibiotic drugs in treating children in the Netherlands is comparable to that in other northern European countries. Broad-spectrum antibiotics were prescribed more frequently than recommended by the guidelines and increased during our study period. Initiatives to improve guideline-directed antibiotic prescribing are strongly recommended.
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