ArticlePsychopharmacology2008
Effects of gastrin-releasing peptide agonist and antagonist administered to the basolateral nucleus of the amygdala on conditioned fear in the rat.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Bombesins: A New Frontier in Hybrid Compound Development.Pharmaceutics · 2023Review
- Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area.Molecular psychiatry · 2022Article
- Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories.Cell · 2021Article
- Serum Metabolites Differentiate Amnestic Mild Cognitive Impairment From Healthy Controls and Predict Early Alzheimer's Disease via Untargeted Lipidomics Analysis.Frontiers in neurology · 2021Article
- Docosahexaenoic Acid Helps to Lessen Extinction Memory in Rats.Molecules (Basel, Switzerland) · 2018Article
- Stress and eating: a dual role for bombesin-like peptides.Frontiers in neuroscience · 2013Article
- Rescue of social behavior impairment by clozapine and alterations in the expression of neuronal receptors in a rat model of neurodevelopmental impairment induced by GRPR blockade.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target.Frontiers in endocrinology · 2012Article
- Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.PloS one · 2012Article
- Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleBombesin (BB)-like peptides have been shown to affect neuroendocrine and neural functions related to the stress response and the modulation of conditioned fear. In line with this view, central administration of gastrin-releasing peptide (GRP; a mammalian analogue of BB) or its receptor antagonist (D-Tpi6, Leu13 psi[CH2NH]-Leu14) BB(6-14) (RC-3095) modulates conditioned fear.
objectiveThe present study examined the effects of bilateral infusions of GRP or its receptor antagonist (RC-3095) into the basolateral nucleus of the amygdala (BLA) on the conditioned emotional response.
methodsThe effects of GRP (150, 300, and 600 ng/0.5 microl) and/or RC-3095 (50, 500, and 1,000 ng/0.5 microl) on contextual and cued fear conditioning were assessed following direct bilateral infusion of these compounds into the BLA.
resultsBoth GRP and RC-3095 (all doses) reduced freezing during the contextual testing period but did not influence responding in the cued test. Although both compounds reduced freezing in the contextual paradigms, at a moderate dose pretreatment with RC-3095 attenuated the GRP-elicited decrease in contextual freezing.
conclusionsIt appears that manipulation of GRP at the BLA may influence the expression of learned fear and that these effects preferentially influence contextual versus cue-dependent emotional responses.
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