ArticleJournal of molecular neuroscience : MN2008
Expression profile of Lgi1 gene in mouse brain during development.
Article in Journal of molecular neuroscience : MN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical characteristics of Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 6-year-old girl: case report and literature reviews.BMC neurology · 2023Review
- Cortical metabolic characteristics of anti-leucine-rich glioma-inactivated 1 antibody encephalitis based onFrontiers in neurology · 2023Article
- The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Cellular and molecular life sciences : CMLS · 2021Review
- LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis.Journal of neuroinflammation · 2018Article
- LGI proteins in the nervous system.ASN neuro · 2013Review
- Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction.Nature reviews. Neuroscience · 2013Review
- Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice.Brain : a journal of neurology · 2010Article
- LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability.Human molecular genetics · 2010Article
- Distribution of the epilepsy-related Lgi1 protein in rat cortical neurons.Histochemistry and cell biology · 2009Article
- Expression profile and distribution of Efhc1 gene transcript during rodent brain development.Journal of molecular neuroscience : MN · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in LGI1 were described in patients with autosomal dominant partial epilepsy with auditory features (ADPEAF), and recent clinical findings have implicated LGI1 in human brain development. However, the precise role of LGI1 in epileptogenesis remains largely unknown. The objective of this study was to determine the expression pattern of Lgi1 in mice brain during development and in adult animals. Real-time polymerase chain reaction (PCR) quantification and Western blot experiments showed a relative low expression during intrauterine stages, increasing until adulthood. In addition, we did not find significant differences between left and right hemispheres. The hippocampus presented higher levels of Lgi1 expression when compared to the neocortex and the cerebellum of adult animals; however, these results did not reach statistical significance. This study was the first to determine a specific profile of Lgi1 gene expression during central nervous system development, which suggests a possible inhibitory function in latter stages of development. In addition, we did not find differences in hemispheric expression that could explain the predominance of left-sided abnormalities in patients with ADPEAF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.