Evidence map›Paper›PMID 18563157›Full record

ArticleNature2008

Micro-engineered local field control for high-sensitivity multispectral MRI.

Gary Zabow, Stephen Dodd, John Moreland, Alan Koretsky

Abstract read
In one paragraph

Article in Nature, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Review
  6. Article
  7. Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.IEEE open journal of engineering in medicine and biology · 2020
    Article
  8. How Non-invasiveFrontiers in physiology · 2020
    Review
  9. Article
  10. Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.The international journal of biochemistry & cell biology · 2018
    Review
  11. Article
  12. Magnetic barcode imaging for contrast agents.Magnetic resonance in medicine · 2017
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. MR susceptibility imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013
    Article
  20. Engineering novel detectors and sensors for MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Gary ZabowLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. zabow@boulder.nist.gov
Stephen Dodd
John Moreland
Alan Koretsky

Funding

MRI contrast for molecular and cellular imaging of the brainZIANS003047 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI KORETSKY, ALAN · 2009 to 2025
$29.3M
MRI contrast for molecular and cellular imaging of the brainZ01NS003047 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI KORETSKY, ALAN · 2007 to 2008
$5.0M
Intramural NIH HHS Z01 NS003047
6 · The paper itself

Abstract

In recent years, biotechnology and biomedical research have benefited from the introduction of a variety of specialized nanoparticles whose well-defined, optically distinguishable signatures enable simultaneous tracking of numerous biological indicators. Unfortunately, equivalent multiplexing capabilities are largely absent in the field of magnetic resonance imaging (MRI). Comparable magnetic-resonance labels have generally been limited to relatively simple chemically synthesized superparamagnetic microparticles that are, to a large extent, indistinguishable from one another. Here we show how it is instead possible to use a top-down microfabrication approach to effectively encode distinguishable spectral signatures into the geometry of magnetic microstructures. Although based on different physical principles from those of optically probed nanoparticles, these geometrically defined magnetic microstructures permit a multiplexing functionality in the magnetic resonance radio-frequency spectrum that is in many ways analogous to that permitted by quantum dots in the optical spectrum. Additionally, in situ modification of particle geometries may facilitate radio-frequency probing of various local physiological variables.

Indexed as

ColorContrast MediaDiffusionMagnetic Resonance ImagingMagneticsSensitivity and SpecificityContrast Media

Identifiers

PMID18563157
PMCPMC6240915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.