ArticleGenome research2008
Insights from the amphioxus genome on the origin of vertebrate neural crest.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 157 citations in OpenAlex.
- Co-option and innovation in neural crest evolution.Science advances · 2026Review
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.Science advances · 2024Article
- Review
- Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.Nucleic acids research · 2023Article
- The developmental and evolutionary origins of cellular pluripotency in the vertebrate neural crest.Seminars in cell & developmental biology · 2023Review
- Making a head: Neural crest and ectodermal placodes in cranial sensory development.Seminars in cell & developmental biology · 2023Review
- Identification of Nodal-dependent enhancer of amphioxus Chordin sufficient to drive gene expression into the chordate dorsal organizer.Development genes and evolution · 2022Article
- Highly distinct genetic programs for peripheral nervous system formation in chordates.BMC biology · 2022Article
- Pax3/7 regulates neural tube closure and patterning in a non-vertebrate chordate.Frontiers in cell and developmental biology · 2022Article
- Riding the crest to get a head: neural crest evolution in vertebrates.Nature reviews. Neuroscience · 2021Review
- Retinoid signaling in skeletal development: Scoping the system for predictive toxicology.Reproductive toxicology (Elmsford, N.Y.) · 2021Review
- The Cranial Neural Crest in a Multiomics Era.Frontiers in physiology · 2021Article
- Mutation of amphioxus Pdx and Cdx demonstrates conserved roles for ParaHox genes in gut, anus and tail patterning.BMC biology · 2020Article
- Network architecture and regulatory logic in neural crest development.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- The origin and evolution of vertebrate neural crest cells.Open biology · 2020Review
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- TheFrontiers in cell and developmental biology · 2020Article
- Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification.Genome research · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The emergence of the neural crest has been proposed to play a key role in early vertebrate evolution by remodeling the chordate head into a "new head" that enabled early vertebrates to shift from filter feeding to active predation. Here we show that the genome of the basal chordate, amphioxus, contains homologs of most vertebrate genes implicated in a putative neural crest gene regulatory network (NC-GRN) for neural crest development. Our survey of gene expression shows that early inducing signals, neural plate border patterning genes, and melanocyte differentiation genes appear conserved. Furthermore, exogenous BMP affects expression of amphioxus neural plate border genes as in vertebrates, suggesting that conserved signals specify the neural plate border throughout chordates. In contrast to this core conservation, many neural crest specifier genes are not expressed at the amphioxus neural plate/tube border, raising the intriguing possibility that this level of the network was co-opted during vertebrate evolution. Consistent with this, the regulatory region of AmphiFoxD, homologous to the vertebrate neural crest specifier FoxD3, drives tissue-specific reporter expression in chick mesoderm, but not neural crest. Thus, evolution of a new regulatory element may have allowed co-option of this gene to the NC-GRN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.