ArticleGenetics2008
The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion and sexual development in Neurospora crassa.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 100 citations in OpenAlex.
- FgCot1 Regulates Polarized Growth and Conidiation in Fusarium graminearum via Gpmk1 MAPK and Tsf1 Transcriptional Pathways.Molecular plant pathology · 2026Article
- Characterization of EOP-1 reveals cell autonomous oscillations preceding somatic cell fusion in Neurospora crassa.PLoS genetics · 2026Article
- Protein Kinase PoxMKK1 Regulates Plant-Polysaccharide-Degrading Enzyme Biosynthesis, Mycelial Growth and Conidiation inJournal of fungi (Basel, Switzerland) · 2023Article
- Regulation of biotic interactions and responses to abiotic stresses by MAP kinase pathways in plant pathogenic fungi.Stress biology · 2021Review
- Coordinated Regulation of Protoperithecium Development by MAP Kinases MAK-1 and MAK-2 inFrontiers in microbiology · 2021Article
- The GUL-1 Protein Binds Multiple RNAs Involved in Cell Wall Remodeling and Affects the MAK-1 Pathway inFrontiers in fungal biology · 2021Article
- Plasma Membrane Fusion Is Specifically Impacted by the Molecular Structure of Membrane Sterols During Vegetative Development ofGenetics · 2020Article
- Clustering analysis of large-scale phenotypic data in the model filamentous fungus Neurospora crassa.BMC genomics · 2020Article
- Two dominant selectable markers for genetic manipulation in Neurospora crassa.Current genetics · 2020Article
- RNAi-Mediated Gene Silencing ofJournal of microbiology and biotechnology · 2020Article
- Crosstalk Between Pheromone Signaling and NADPH Oxidase Complexes Coordinates Fungal Developmental Processes.Frontiers in microbiology · 2020Article
- Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication inGenetics · 2019Article
- Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi.World journal of microbiology & biotechnology · 2019Review
- Communicate and Fuse: How Filamentous Fungi Establish and Maintain an Interconnected Mycelial Network.Frontiers in microbiology · 2019Review
- Regulation of Cell-to-Cell Communication and Cell Wall Integrity by a Network of MAP Kinase Pathways and Transcription Factors inGenetics · 2018Article
- Three Fusarium oxysporum mitogen-activated protein kinases (MAPKs) have distinct and complementary roles in stress adaptation and cross-kingdom pathogenicity.Molecular plant pathology · 2017Article
- Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.Microbiology spectrum · 2017Review
- Regulation of Neurospora crassa cell wall remodeling via the cot-1 pathway is mediated by gul-1.Current genetics · 2017Article
- Accumulation of specific sterol precursors targets a MAP kinase cascade mediating cell-cell recognition and fusion.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Colletotrichum graminicola striatin orthologue Str1 is necessary for anastomosis and is a virulence factor.Molecular plant pathology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ndr kinases, such as Neurospora crassa COT1, are important for cell differentiation and polar morphogenesis, yet their input signals as well as their integration into a cellular signaling context are still elusive. Here, we identify the cot-1 suppressor gul-4 as mak-2 and show that mutants of the gul-4/mak-2 mitogen-activated protein (MAP) kinase pathway suppress cot-1 phenotypes along with a concomitant reduction in protein kinase A (PKA) activity. Furthermore, mak-2 pathway defects are partially overcome in a cot-1 background and are associated with increased MAK1 MAPK signaling. A comparative characterization of N. crassa MAPKs revealed that they act as three distinct modules during vegetative growth and asexual development. In addition, common functions of MAK1 and MAK2 signaling during maintenance of cell-wall integrity distinguished the two ERK-type pathways from the p38-type OS2 osmosensing pathway. In contrast to separate functions during vegetative growth, the concerted activity of the three MAPK pathways is essential for cell fusion and for the subsequent formation of multicellular structures that are required for sexual development. Taken together, our data indicate a functional link between COT1 and MAPK signaling in regulating filamentous growth, hyphal fusion, and sexual development.
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