ArticleAmerican journal of physiology. Renal physiology2008
Mechanism of dietary salt-mediated increase in intravascular production of TGF-beta1.
Article in American journal of physiology. Renal physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Immunology of Hypertension: Pathophysiological and Therapeutic Aspects.International journal of molecular sciences · 2025Review
- Salt sensitivity and hypertension.Journal of human hypertension · 2021Review
- Construction of a Nanosensor for Non-Invasive Imaging of Hydrogen Peroxide Levels in Living Cells.Biology · 2020Article
- Cardiotonic Steroids-A Possible Link Between High-Salt Diet and Organ Damage.International journal of molecular sciences · 2019Review
- Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions.PloS one · 2019Article
- Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats.International journal of molecular sciences · 2018Article
- Renal effects of cytokines in hypertension.Current opinion in nephrology and hypertension · 2018Review
- Novel Paradigms of Salt and Hypertension.Journal of the American Society of Nephrology : JASN · 2017Review
- Proteomic and phosphoproteomic analysis of renal cortex in a salt-load rat model of advanced kidney damage.Scientific reports · 2016Article
- Age-Related Macular Degeneration and Intracrine Biology: An Hypothesis.Ochsner journal · 2016Review
- Transforming growth factor-β mediates endothelial dysfunction in rats during high salt intake.American journal of physiology. Renal physiology · 2015Article
- Urinary sodium excretion has positive correlation with activation of urinary renin angiotensin system and reactive oxygen species in hypertensive chronic kidney disease.Journal of Korean medical science · 2014Article
- Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.American journal of physiology. Renal physiology · 2014Article
- The role of transforming growth factor β1 in the regulation of blood pressure.Current hypertension reviews · 2014Review
- Transforming growth factor-β regulates endothelial function during high salt intake in rats.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury.Physiological genomics · 2013Article
- Dietary salt intake is related to inflammation and albuminuria in primary hypertensive patients.European journal of clinical nutrition · 2012Article
- High salt intake causes adverse fetal programming--vascular effects beyond blood pressure.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Renoprotective effects of anti-TGF-β antibody and antihypertensive therapies in Dahl S rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Effect of dietary salt on regulation of TGF-β in the kidney.Seminars in nephrology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Clinical and preclinical studies have demonstrated an important effect of arterial pathobiology on the progressive loss of renal function that occurs in chronic kidney disease. Chronic kidney disease, in turn, promotes alterations in vascular function. A modulating role for dietary salt has been suggested, with the amount of salt intake regulating endothelial cell production of transforming growth factor-beta1 (TGF-beta1), a fibrogenic growth factor that promotes arteriosclerosis and glomerulosclerosis. The purpose of the present studies was to determine how the interaction between dietary salt intake and vasculature promoted the production of TGF-beta1 in rats. Two different vascular tissues, aortic rings and glomeruli, were chosen for study. Dietary salt induced, in a dose-dependent fashion, activation of proline-rich tyrosine kinase-2 (Pyk2) and further identified c-Src as an important binding partner of Pyk2 in these tissues. Use of pharmacological inhibitors and dominant negative strategies confirmed that dietary salt induced complex formation of Pyk2 and c-Src with downstream activation of p38 and p42/44 mitogen-activated protein kinases and generation of TGF-beta1. The experiments defined the molecular signaling events that promoted the production of TGF-beta1, a key growth factor involved in the vascular response to increased salt intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.