ArticleJournal of clinical microbiology2008
Pediatric norovirus diarrhea in Nicaragua.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Community-based surveillance of norovirus disease: a systematic review.BMC infectious diseases · 2017Pooled it
- Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea.Cell host & microbe · 2024Article
- Epidemiology of Pediatric Astrovirus Gastroenteritis in a Nicaraguan Birth Cohort.Open forum infectious diseases · 2024Article
- Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran.Infection prevention in practice · 2024Article
- Norovirus in children under 2 years of age: an epidemiological study in Panama during the COVID-19 pandemic.Frontiers in pediatrics · 2024Article
- Molecular Characterization of Enteric Viruses Causing Acute Gastroenteritis among Children under 5 Years Old in Distrito Central, Honduras.Intervirology · 2024Article
- Viral load at hospitalization is an independent predictor of severe COVID-19.European journal of clinical investigation · 2023Article
- Molecular characterization of norovirus and sapovirus detected in animals and humans in Costa Rica: Zoo-anthropozoonotic potential of human norovirus GII.4.Open veterinary journal · 2023Article
- Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort.PloS one · 2022Article
- Norovirus and rotavirus in children hospitalised with diarrhoea after rotavirus vaccine introduction in Burkina Faso.Epidemiology and infection · 2020Article
- Histo-blood group antigens and rotavirus vaccine shedding in Nicaraguan infants.Scientific reports · 2019Article
- Review
- Genetic diversity of norovirus in children under 5 years of age with acute gastroenteritis from Angola.Epidemiology and infection · 2018Article
- Pediatric norovirus GII.4 infections in Nicaragua, 1999-2015.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2017Article
- Risk Factors for Norovirus Gastroenteritis among Nicaraguan Children.The American journal of tropical medicine and hygiene · 2017Article
- High prevalence of GII norovirus in hospitalized children with acute diarrhea, in Beijing.PloS one · 2017Article
- High Prevalence and Increased Severity of Norovirus Mixed Infections Among Children 12-24 Months of Age Living in the Suburban Areas of Lima, Peru.Journal of the Pediatric Infectious Diseases Society · 2016Article
- The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin.Archives of virology · 2016Article
- Innate Resistance and Susceptibility to Norovirus Infection.PLoS pathogens · 2016Review
- Norovirus Epidemiology in Africa: A Review.PloS one · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information about norovirus (NoV) infections in Central America is limited. Through a passive community and hospital pediatric diarrhea surveillance program, a total of 542 stool samples were collected between March 2005 and February 2006 in León, Nicaragua. NoV was detected in 12% (65/542) of the children; of these, 11% (45/409) were in the community and 15% (20/133) were in the hospital, with most strains (88%) belonging to genogroup II. NoV infections were age and gender associated, with children of <2 years of age (P < 0.05) and girls (P < 0.05) being most affected. Breast-feeding did not reduce the number of NoV infections. An important proportion (57%) of NoV-infected children were coinfected with diarrheagenic Escherichia coli. A significant proportion (18/31) of NoV-positive children with dehydration required intravenous rehydration. Nucleotide sequence analysis (38/65) of the N-terminal and shell region in the capsid gene revealed that at least six genotypes (GI.4, GII.2, GII.4, GII.7, GII.17, and a potentially novel cluster termed "GII.18-Nica") circulated during the study period, with GII.4 virus being predominant (26/38). The majority (20/26) of those GII.4 strains shared high nucleotide homology (99%) with the globally emerging Hunter strain. The mean viral load was approximately 15-fold higher in children infected with GII.4 virus than in those infected with other G.II viruses, with the highest viral load observed for the group of children infected with GII.4 and requiring intravenous rehydration. This study, the first of its type from a Central American country, suggests that NoV is an important etiological agent of acute diarrhea among children of <2 years of age in Nicaragua.
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