ArticleAmerican journal of physiology. Cell physiology2008
oxLDL facilitates flow-induced realignment of aortic endothelial cells.
Article in American journal of physiology. Cell physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- OxLDL and substrate stiffness promote neutrophil transmigration by enhanced endothelial cell contractility and ICAM-1.Journal of biomechanics · 2012Trial
- The Importance of the Plasma Membrane in Atherogenesis.Membranes · 2022Review
- Caveolin-1 is a primary determinant of endothelial stiffening associated with dyslipidemia, disturbed flow, and ageing.Scientific reports · 2022Article
- Oxidised Low-Density Lipoprotein-Induced Platelet Hyperactivity-Receptors and Signalling Mechanisms.International journal of molecular sciences · 2022Review
- Paradigms of endothelial stiffening in cardiovascular disease and vascular aging.Frontiers in physiology · 2022Review
- Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology.International journal of molecular sciences · 2021Review
- The interplay of membrane cholesterol and substrate on vascular smooth muscle biomechanics.Current topics in membranes · 2020Article
- Cholesterol Depletion by MβCD Enhances Cell Membrane Tension and Its Variations-Reducing Integrity.Biophysical journal · 2019Article
- oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27American journal of physiology. Cell physiology · 2017Article
- Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.Biophysical journal · 2017Article
- Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation.Journal of lipid research · 2016Article
- Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture.Journal of biomedical optics · 2013Review
- Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior.Journal of biomedical materials research. Part A · 2013Article
- Overexpression of actin-depolymerizing factor blocks oxidized low-density lipoprotein-induced mouse brain microvascular endothelial cell barrier dysfunction.Molecular and cellular biochemistry · 2012Article
- Micropipette aspiration of substrate-attached cells to estimate cell stiffness.Journal of visualized experiments : JoVE · 2012Article
- The role of oxysterols in control of endothelial stiffness.Journal of lipid research · 2012Article
- Impact of oxLDL on Cholesterol-Rich Membrane Rafts.Journal of lipids · 2011Article
- Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011Article
- oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation.American journal of physiology. Cell physiology · 2010Article
- Oxidized LDL: diversity, patterns of recognition, and pathophysiology.Antioxidants & redox signaling · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Alignment of vascular endothelial cells (ECs) in the direction of the flow is considered a key factor in maintaining endothelial integrity in an active hemodynamic environment. Our recent studies showed that exposure to oxidized LDL (oxLDL), one of the major proatherogenic lipoproteins, significantly increases the stiffness of human aortic ECs, suggesting that oxLDL may have a significant impact on the sensitivity of ECs to mechanical stimuli. In this study, we show that oxLDL strongly enhances the ability of ECs to realign in the direction of the flow and facilitates the formation of F-actin stress fibers under static and flow conditions. The impact of oxLDL on the flow-induced realignment is observed on whole cell and single-fiber levels. We also show that, similar to the effect of oxLDL on endothelial stiffness, the impact of oxLDL on flow-induced realignment can be simulated by methyl-beta-cyclodextrin-induced cholesterol depletion, supporting the hypothesis that oxLDL acts as cholesterol acceptor, rather than cholesterol donor, for ECs. Finally, we propose that oxLDL/cholesterol depletion-induced sensitization of ECs to flow may be a result of an increase in cellular stiffness and a respective increase in membrane-cytoskeleton tension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.