ArticleSchizophrenia bulletin2010
Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia.
Article in Schizophrenia bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Eye movement dysfunction in first-degree relatives of patients with schizophrenia: a meta-analytic evaluation of candidate endophenotypes.Brain and cognition · 2008Pooled it
- Does performance on the standard antisaccade task meet the co-familiality criterion for an endophenotype?Brain and cognition · 2008Pooled it
- Association Between the rs4680 Polymorphism of the COMT Gene and Personality Traits among Combat Sports Athletes.Journal of human kinetics · 2023Article
- Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China.International journal of environmental research and public health · 2021Article
- COMT and GAD1 gene polymorphisms are associated with impaired antisaccade task performance in schizophrenic patients.European archives of psychiatry and clinical neuroscience · 2018Article
- Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study.Psychophysiology · 2014Article
- Contributions of COMT Val¹⁵⁸ Met to cognitive stability and flexibility in infancy.Developmental science · 2014Article
- Relating dopaminergic and cholinergic polymorphisms to spatial attention in infancy.Developmental psychology · 2014Article
- Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype.European archives of psychiatry and clinical neuroscience · 2012Article
- Variation in genes involved in dopamine clearance influence the startle response in older adults.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Neuregulin-1 genotypes and eye movements in schizophrenia.European archives of psychiatry and clinical neuroscience · 2010Article
- Article
- Electrophysiological Endophenotypes for Schizophrenia.Harvard review of psychiatryReview
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7 authors.
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Abstract
The catechol-O-methyltransferase (COMT) enzyme catabolizes dopamine. The val(158)met single nucleotide polymorphism (rs4680) in the COMT gene has received considerable attention as a candidate gene for schizophrenia as well as for frontally mediated cognitive functions. Antisaccade performance is a good measure of frontal lobe integrity. Deficits on the task are considered a trait marker for schizophrenia. The aim of this study was to investigate the association of COMT val(158)met polymorphism with antisaccade eye movements in schizophrenia patients and healthy controls. Schizophrenia patients (N = 105) and healthy controls (N = 95) underwent infrared oculographic assessment of antisaccades. Subjects were genotyped for COMT val(158)met and divided into 3 groups according to genotype (val/val, val/met, and met/met). Patients displayed significantly more reflexive errors, longer and more variable latency, and lower amplitude gain than controls (all P < 0.02). A greater number of val(158) alleles was associated with shorter (P = 0.045) and less variable (P = 0.028) antisaccade latency and, nonsignificantly, with lower reflexive error rate (P = 0.056). None of these variables showed a group-by-genotype interaction (P > 0.1). There were no significant associations of genotype with measures of amplitude gain or spatial error (P > 0.2). The results suggest that COMT val(158) carrier status is associated with better performance on the antisaccade task. Possible explanations of this finding are discussed.
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