ArticleProceedings of the National Academy of Sciences of the United States of America2008
Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Central tolerance is impaired in the middle-aged thymic environment.Aging cell · 2022Article
- Impact of Early Versus Late Antiretroviral Treatment Initiation on Naive T Lymphocytes in HIV-1-Infected Children and Adolescents - The-ANRS-EP59-CLEAC Study.Frontiers in immunology · 2021Article
- Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART.Viruses · 2019Review
- Article
- Critical influence of the thymus on peripheral T cell homeostasis.Immunity, inflammation and disease · 2016Article
- Mechanisms of diabetic autoimmunity: I--the inductive interface between islets and the immune system at onset of inflammation.Immunologic research · 2016Review
- Mechanisms of diabetic autoimmunity: II--Is diabetes a central or peripheral disorder of effector and regulatory cells?Immunologic research · 2016Review
- How many TCR clonotypes does a body maintain?Journal of theoretical biology · 2016Article
- Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy.Immunity & ageing : I & A · 2016Article
- Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV-infected individuals.Southern African journal of HIV medicine · 2016Article
- Global stability of infection-free state and endemic infection state of a modified human immunodeficiency virus infection model.IET systems biology · 2015Article
- Zap70 is essential for long-term survival of naive CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.Immunity & ageing : I & A · 2014Article
- Dynamics analysis and simulation of a modified HIV infection model with a saturated infection rate.Computational and mathematical methods in medicine · 2014Article
- Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue.Immunity & ageing : I & A · 2014Article
- The effect of age on thymic function.Frontiers in immunology · 2013Review
- A mathematical model of immune activation with a unified self-nonself concept.Frontiers in immunology · 2013Article
- NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology.PLoS biology · 2013Article
- Nonalloreactive T cells prevent donor lymphocyte infusion-induced graft-versus-host disease by controlling microbial stimuli.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
A model of chemical thymectomy by inducible Rag ablation was used to study peripheral T cell homeostasis. Induction of Rag ablation was efficient and complete, leading to cessation of thymic T cell production within 3-4 weeks. The decay of peripheral T cells became apparent with a delay of an additional 2-3 weeks and was entirely accounted for by loss of naïve T cells, whereas numbers of memory phenotype and regulatory T cells were not decreased. Naïve CD4 T cells decayed with an average half-life of 50 days, whereas naïve CD8 T cells exhibited a considerably longer half-life. The rapid decay of naïve CD4 T cells was not caused by intrinsic survival differences compared with naïve CD8 T cells, but was caused by changes in the lymphopenic environment resulting in higher microbial load and consequential activation. This finding suggests that in lymphopenic conditions involving compromised thymic function replenishment and survival of a naïve CD4 T cell repertoire may be severely curtailed because of chronic activation. Such a scenario might play a role in the aging immune system and chronic viral infection, such as HIV infection, and contribute to loss of CD4 T cells and impaired immune function. As our data show, continued replenishment with cells from the thymus seems to be required to maintain efficient gut mucosal defense.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.