ArticleProceedings of the National Academy of Sciences of the United States of America2008
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 39 citations in OpenAlex.
- Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53.Cell reports · 2023Article
- The regulation of transcription elongation in embryonic stem cells.Frontiers in cell and developmental biology · 2023Review
- Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases.Cellular and molecular life sciences : CMLS · 2022Review
- Sequence, structural and functional conservation among the human and fission yeast ELL and EAF transcription elongation factors.Molecular biology reports · 2022Article
- Article
- Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression.Genes & development · 2021Article
- Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.Molecular immunology · 2017Article
- O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.The Journal of biological chemistry · 2016Article
- RNAi screen in Drosophila larvae identifies histone deacetylase 3 as a positive regulator of the hsp70 heat shock gene expression during heat shock.Biochimica et biophysica acta · 2014Article
- A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.Biochemistry · 2014Article
- ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1.Molecular and cellular biology · 2014Article
- Transcriptional elongation checkpoint control in development and disease.Genes & development · 2013Review
- Recognition of methylated peptides by Drosophila melanogaster polycomb chromodomain.Journal of proteome research · 2013Article
- Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.Molecular and cellular biology · 2012Article
- Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.Genetics research international · 2012Article
- RNA polymerase II elongation control.Annual review of biochemistry · 2012Review
- The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.Annual review of biochemistry · 2012Review
- Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila.PLoS genetics · 2012Article
- The little elongation complex regulates small nuclear RNA transcription.Molecular cell · 2011Article
- Human mediator subunit MED26 functions as a docking site for transcription elongation factors.Cell · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Many developmentally regulated genes contain a poised RNA polymerase II (Pol II) at their promoters under conditions where full-length transcripts are undetectable. It has been proposed that the transcriptional activity of such promoters is regulated at the elongation stage of Pol II transcription. In Drosophila, the heat-shock loci expressing the Hsp70 genes have been used as a model for the regulation of the transcriptional activity of poised Pol II. Drosophila ELL (dELL) is a Pol II elongation factor capable of stimulating the rate of transcription both in vivo and in vitro. Although ELL and the elongation factor Elongin A have indistinguishable effects on RNA polymerase in vitro, the loss-of-function studies indicate that these proteins are not redundant in vivo. In this article, we use RNAi to investigate the physiological properties of dELL and a dELL-associated factor (dEaf) in a living organism. Both ELL and Eaf are essential for fly development. dELL is recruited to heat shock loci upon induction, and its presence with Pol II at such loci is required for proper heat-shock gene expression. Consistent with a role in elongation, dELL knockdown reduces the levels of phosphorylated Pol II at heat-shock loci. This study implicates dELL in the expression of loci regulated by Pol II elongation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.