ReviewCurrent opinion in pharmacology2008
Neuroimmunology of central nervous system viral infections: the cells, molecules and mechanisms involved.
Review in Current opinion in pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Viral immunological complications in neurological surgery: A comprehensive review of homeostatic disturbances and cognitive impairments.Surgical neurology international · 2025Review
- Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy.Cell reports. Medicine · 2024Article
- New insight into DAVF pathology-Clues from meningeal immunity.Frontiers in immunology · 2022Review
- New advances in CNS immunity against viral infection.Current opinion in virology · 2018Review
- Interferon regulated gene (IRG) expression-signature in a mouse model of chikungunya virus neurovirulence.Journal of neurovirology · 2017Article
- Depletion of FoxP3Immunity, inflammation and disease · 2017Article
- Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis.The Journal of general virology · 2016Article
- Protein kinase C activation mediates interferon-β-induced neuronal excitability changes in neocortical pyramidal neurons.Journal of neuroinflammation · 2014Article
- Rift valley Fever virus encephalitis is associated with an ineffective systemic immune response and activated T cell infiltration into the CNS in an immunocompetent mouse model.PLoS neglected tropical diseases · 2014Article
- Immune responses to non-tumor antigens in the central nervous system.Frontiers in oncology · 2014Review
- Adaptive immune response to viral infections in the central nervous system.Handbook of clinical neurology · 2014Article
- Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.Journal of immunology research · 2014Article
- Article
- Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.PloS one · 2013Article
- Article
- NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.Nature medicine · 2012Article
- Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection.Scientific reports · 2012Article
- Viral CNS infections: role of glial pattern recognition receptors in neuroinflammation.Frontiers in microbiology · 2012Article
- Tregs and infections: on the potential value of modifying their function.Journal of leukocyte biology · 2011Review
- Clearance of virus infection from the CNS.Current opinion in virology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Viral infections of the central nervous system (CNS) necessitate rapid, yet tightly controlled responses to contain viral spread while limiting tissue damage. All CNS resident cell types are equipped with pattern recognition receptors (PRRs) to respond to viruses. The resulting activation of IFN-alpha/beta, pro-inflammatory cytokines and chemokines is dependent on the virus replication strategy, tropism and PRR distribution. Although IFN-alpha/beta induced antiviral mediators are essential to restrict initial viral spread, adaptive immunity promoted by chemokines, cytokines and metalloproteinases is equally crucial in lowering viral burden. Recognition of viral antigen presented by MHC molecules is crucial for T cell retention and function. Non-lytic clearance mechanisms mediated by IFN-gamma and antibodies prevail in providing protection. Targeted intervention can be achieved by PRR stimulation, chemokine-receptor blockade and immune modulation of T cell function. However, owing to the extensive positive and negative feedback signaling cascades linking innate and adaptive immune responses, enhanced anti-viral functions will have to be counterbalanced to avoid pathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.