Trial reportPediatric nephrology (Berlin, Germany)2008
Antenatal hydronephrosis: infants with minor postnatal dilatation do not need prophylaxis.
Trial report in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Antibiotic prophylaxis for prevention of urinary tract infections in the first year of life in children with vesicoureteral reflux diagnosed in the workup of antenatal hydronephrosis: a systematic review.Pediatric nephrology (Berlin, Germany) · 2020Pooled it
- The role of antibiotic prophylaxis in mild to moderate isolated hydronephrosis detected in antenatal screening.Investigative and clinical urology · 2020Trial
- Outcomes of antenatal hydronephrosis and other renal abnormalities in a population-based cohort.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Antenatally detected urinary tract dilatation: long-term outcome.Pediatric nephrology (Berlin, Germany) · 2023Review
- Antenatally detected urinary tract dilatation: a 12-15-year follow-up.Pediatric nephrology (Berlin, Germany) · 2020Article
- Guidelines for the medical management of pediatric vesicoureteral reflux.International journal of urology : official journal of the Japanese Urological Association · 2020Article
- [Congenital dilatation of the upper urinary tract : Current diagnostic and treatment concepts].Der Urologe. Ausg. A · 2018Article
- Ultrasonography of hydronephrosis in the newborn: a practical review.Ultrasonography (Seoul, Korea) · 2016Review
- From Research Question to Conducting a Randomized Controlled Trial on Continuous Antibiotic Prophylaxis in Prenatal Hydronephrosis: A Rational Stepwise Process.Frontiers in pediatrics · 2016Article
- Revised guidelines on management of antenatal hydronephrosis.Indian journal of nephrology · 2013Article
- Natural history of bilateral mild isolated antenatal hydronephrosis conservatively managed.Pediatric nephrology (Berlin, Germany) · 2012Article
- Antibiotic prophylaxis in antenatal nonrefluxing hydronephrosis, megaureter and ureterocele.Nature reviews. Urology · 2012Review
- Clinical spectrum of antenatally detected urinary tract abnormalities with respect to hydronephrosis at postnatal ultrasound scan.Pediatric surgery international · 2012Article
- Probability of urinary tract infection in infants with ureteropelvic junction obstruction: is antibacterial prophylaxis really needed?Pediatric nephrology (Berlin, Germany) · 2011Article
- Outcome and management of isolated moderate renal pelvis dilatation detected at postnatal screening.Pediatric nephrology (Berlin, Germany) · 2009Article
- Postnatal evaluation of infants with an abnormal antenatal renal sonogram.Current opinion in pediatrics · 2009Review
- Isolated low grade prenatally detected unilateral hydronephrosis: do we need long term follow-up?International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine the occurrence of urinary tract infection (UTI) in infants with antenatal renal pelvis dilatation (ARPD). Consecutive ultrasound (US) screening of 14,000 pregnant women detected ARPD >or=5 mm in 106 foetuses. After birth, two US examinations were performed: on the fifth to seventh day and during the third week of life. The findings were considered normal when renal pelvis dilatation (RPD) was <or=7 mm on both examinations and no other signs of abnormality were present. Voiding cystourethrography (VCUG) was done in all infants 6-8 weeks after birth. One hundred and three infants were followed for 2 years. Antibacterial prophylaxis (trimethoprim 1 mg/kg per day) was given to those with RPD >or=15 mm, vesicoureteric reflux (VUR) grades III-V and suspected obstruction. In 53/103 babies, both US examinations were normal, three had VUR grade I. Two girls had UTI at 18 and 24 months of age, respectively. Among the 50 infants with abnormal initial US, six had VUR, of which four were high grade (IV-V). All four developed UTI. We conclude that UTI is uncommon in infants with two normal postnatal US examinations. Routine use of antibacterial prophylaxis in these infants therefore cannot be recommended.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.