ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2009
Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2024Article
- Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology.Frontiers in genetics · 2020Review
- Comparative Analysis of Microbiome in Nasopharynx and Middle Ear in Young Children With Acute Otitis Media.Frontiers in genetics · 2019Article
- Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion.Scientific reports · 2016Article
- Otitis media.Nature reviews. Disease primers · 2016Review
- Association of cytokine gene polymorphisms and risk factors with otitis media proneness in children.European journal of pediatrics · 2016Article
- Evidence and evidence gaps in the treatment of Eustachian tube dysfunction and otitis media.GMS current topics in otorhinolaryngology, head and neck surgery · 2016Review
- Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation.Medicine · 2015Observational
- Importance of viruses in acute otitis media.Current opinion in pediatrics · 2015Review
- Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms.The Laryngoscope · 2014Article
- Article
- Panel 5: Microbiology and immunology panel.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2013Review
- Current knowledge of the genetics of otitis media.Current allergy and asthma reports · 2012Review
- Cytokine responses in the common cold and otitis media.Current allergy and asthma reports · 2012Review
- Article
- Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice.Genome biology · 2011Article
- Unraveling the genetics of otitis media: from mouse to human and back again.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Interleukin-6⁻¹⁷⁴ and tumor necrosis factor α⁻³⁰⁸ polymorphisms enhance cytokine production by human macrophages exposed to respiratory viruses.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
- CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness.The Journal of infectious diseases · 2010Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies suggested that the otitis media (OM) complication rate of viral upper respiratory infection (vURI) is conditioned by genes affecting cytokine production. Two hundred and thirty children (114 male; 187 White, 25 Black; aged 1-9.3 years, average=3.6+/-1.6 years) were prospectively followed over the typical cold season for cold-like illness and OM. Nasopharyngeal secretion samples collected during cold-like illness and OM were assayed for upper respiratory viruses and buccal samples were assayed for TNFalpha (-308), IL-10(-1082, -819, -592), IL-6 (-174) and IFN-gamma (+874) polymorphisms. Logistic regression was used to identify genotypes that predict OM coincident with RSV and rhinovirus (RV) infection. Of the 157 children with RV detection (79 male; 132 White, 13 Black, 12 Other; aged 3.6+/-1.5 years), simple logistic regression identified age (B= -0.34, Z= -2.8, P<0.01, OR=0.71), IL-6 (B= -0.76, Z= -3.3, P<0.01, OR=0.47) and IL-10 (B=0.49, Z=2.0, P=0.05, OR=1.6) as significant predictors of OM coincidence. A more complex logistic regression model for RV detection that included selected OM risk factors identified these factors as well as the TNFalpha genotype, OM history, breastfeeding history and daily environment as significant predictors of OM coincidence. Of the 43 children with RSV detection (21 male; 35 White, 5 Black, 3 Other, aged 3.9+/-1.7 years), logistic regression identified IL-10 (B=1.05, Z=2.0, P=0.05, OR=2.9) as a significant predictor of OM coincidence. New OM episodes coincident with evidence of RSV and RV infection were significantly more frequent in children with high production IL-10 phenotypes. The low production IL-6 and high production TNFalpha phenotypes also contributed to OM risk during RV detection. Cytokine polymorphisms may be one of an expectedly large number of genetic factors contributing to the known heritability of OM.
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