Trial reportUrological research2008
Citraturic, alkalinizing and antioxidative effects of limeade-based regimen in nephrolithiasis patients.
Trial report in Urological research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Citrate salts for preventing and treating calcium containing kidney stones in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Lime-based supplement reduces calcium oxalate stone recurrence: A multicenter randomized controlled trial.PloS one · 2025Trial
- Lime powder treatment reduces urinary excretion of total protein and transferrin but increases uromodulin excretion in patients with urolithiasis.Urolithiasis · 2018Trial
- Effects of a commercial lemonade beverage, potassium citrate, and combination therapy on urinary stone risk parameters in hypocitraturic stone formers: a randomized crossover trial.Translational andrology and urology · 2026Article
- Antiplasmodial potential of phytochemicals from Citrus aurantifolia peels: a comprehensive in vitro and in silico study.BMC chemistry · 2024Article
- Dietary advice for patients with bowel-related conditions and malabsorption.World journal of urology · 2023Review
- Lime juice as a dietary alternative to mist potassium citrate for urine alkalinisation: A prospective, cross-over clinical trial.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023Article
- Cold-pressed oil fromExperimental and therapeutic medicine · 2022Article
- Review
- Urinary stone risk factors in the descendants of patients with kidney stone disease.Pediatric nephrology (Berlin, Germany) · 2018Article
- Epidemiology of stone disease across the world.World journal of urology · 2017Review
- Combination of vitamin E and vitamin C alleviates renal function in hyperoxaluric rats via antioxidant activity.The Journal of veterinary medical science · 2017Article
- Effect of citrus-based products on urine profile: A systematic review and meta-analysis.F1000Research · 2017Article
- Treatment of patients with uric acid stones.Urolithiasis · 2016Review
- An ethnobotanical survey of medicinal plants in Trinidad.Journal of ethnobiology and ethnomedicine · 2015Article
- In vitro anti-lithogenic activity of lime powder regimen (LPR) and the effect of LPR on urinary risk factors for kidney stone formation in healthy volunteers.Urolithiasis · 2015Article
- Increased oxidative DNA damage seen in renal biopsies adjacent stones in patients with nephrolithiasis.Urolithiasis · 2014Article
- Urolithiasis presenting as right flank pain: a case report.The Journal of the Canadian Chiropractic Association · 2013Article
- Dietary therapy for patients with hypocitraturic nephrolithiasis.Nature reviews. Urology · 2011Review
- Anticancer Activity of Key Lime,Pharmacognosy reviewsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potassium citrate has long been used as a prophylactic remedy for nephrolithiasis recurrence. Lemonade consumption is also suggested as an option. We compared the efficacy of consumption of solution containing manufactured lime powder with that of potassium citrate, on the improvement of metabolic risk factors, oxidative stress and renal tubular damage in nephrolithiasis patients. Patients with kidney stone were enrolled and randomly assigned to three treatment programs for 3 month period consisting of consumption of solution containing lime powder (Group 1, n=13), potassium citrate (Group 2, n=11) and lactose as placebo regimen (Group 3, n=7). Lime powder and potassium citrate contained equal amounts of potassium (21 mEq) and citrate (63 mEq). After treatment, there was an increase in urinary pH, potassium and citrate in Group 1 and 2. Increased plasma potassium and red blood cell glutathione (R-GSH) and decreased urinary malondialdehyde were found in Group 1, but not observed in Group 2. R-GSH was decreased in Group 2. Urinary N-acetyl-beta-glucosaminidase activity and fractional excretion of magnesium, as renal tubular damage indicators, were decreased only in Group 1. In Group 3, all measured parameters were unaltered except for an increased urinary chloride. In conclusion, consumption of our in-house lime powder exerted citraturic and alkalinizing actions as efficient as consumption of potassium citrate. In addition, it provided an antioxidative effect and was able to attenuate renal tubular damage. These pharmacological properties may be clinically useful to diminish the stone-forming potential in kidney stone patients and hence for preventing recurrent calculi.
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