ArticleDiabetologia2008
A cross-sectional study of the association between persistent organic pollutants and glucose intolerance among Greenland Inuit.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis.Environmental health perspectives · 2013Pooled it
- Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases.Nature reviews. Endocrinology · 2026Review
- Association of joint exposure to organophosphorus flame retardants and phthalate acid esters with gestational diabetes mellitus: a nested case-control study.BMC pregnancy and childbirth · 2024Article
- Serum concentration of polychlorinated biphenyls and the risk of type 2 diabetes: a 10-year follow-up historical cohort study.Scientific reports · 2024Article
- Critical Overview on Endocrine Disruptors in Diabetes Mellitus.International journal of molecular sciences · 2023Review
- Persistent organic pollutants and β-cell toxicity: a comprehensive review.American journal of physiology. Endocrinology and metabolism · 2022Review
- Type 2 Diabetes Induced by Changes in Proteomic Profiling of Zebrafish Chronically Exposed to a Mixture of Organochlorine Pesticides at Low Concentrations.International journal of environmental research and public health · 2022Article
- An overview of organic contaminants in indoor dust, their health impact, geographical distribution and recent extraction/analysis methods.Environmental geochemistry and health · 2022Review
- Human health risks due to airborne polychlorinated biphenyls are highest in New Bedford Harbor communities living closest to the harbor.The Science of the total environment · 2020Article
- Longitudinal association of biomarkers of pesticide exposure with cardiovascular disease risk factors in youth with diabetes.Environmental research · 2020Article
- Long-term metabolic consequences of acute dioxin exposure differ between male and female mice.Scientific reports · 2020Article
- Prenatal dioxin exposure and glucose metabolism in the Seveso Second Generation study.Environment international · 2020Article
- Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells.Frontiers in endocrinology · 2020Article
- Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure.Diabetologia · 2020Article
- Examining environmental contaminant mixtures among adults with type 2 diabetes in the Cree First Nation communities of Eeyou Istchee, Canada.Scientific reports · 2019Article
- Diabetes care in the dispersed population of Greenland. A new model based on continued monitoring, analysis and adjustment of initiatives taken.International journal of circumpolar health · 2019Article
- The Relationship between Persistent Organic Pollutants Exposure and Type 2 Diabetes among First Nations in Ontario and Manitoba, Canada: A Difference in Difference Analysis.International journal of environmental research and public health · 2018Article
- Persistent Organic Pollutants and Type 2 Diabetes: A Critical Review of Review Articles.Frontiers in endocrinology · 2018Review
- Polychlorinated biphenyls and links to cardiovascular disease.Environmental science and pollution research international · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisSome evidence supports the hypothesis that persistent organic pollutants (POPs) may increase the risk of type 2 diabetes. The Inuit population in Greenland, which is highly exposed to POPs due to a high intake of marine mammals, has experienced a rapid increase in diabetes prevalence over the last 30 years. Thus the aim was to study the association between POPs and glucose intolerance and markers of insulin resistance and insulin secretion using a population-based design.
methodsFrom 1999 to 2002 the Greenland population study was carried out among adult Inuit living in Greenland. The examination included a 75 g OGTT, anthropometric measurements, a structured interview, and blood tests. Plasma glucose and serum insulin were analysed, and three defined subclasses of POPs were analysed in a subgroup. Associations were adjusted for age, sex, waist circumference, Inuit heritage, cigarette smoking, alcohol consumption and educational level.
resultsData on POPs were available on 692 individuals, 305 men (mean age 50 years) and 387 women (mean age 49 years). The prevalence of diabetes was 10.3%, and 10.5% had impaired glucose tolerance. The concentrations of several POPs were exceptionally high. While no associations were found between POPs and stages of glucose intolerance or markers of insulin resistance, POPs were significantly inversely associated with stimulated insulin concentrations and homeostasis model assessment of beta cell function. CONCLUSIONS/
interpretationThe study indicates that POPs may affect insulin secretion rather than being involved in the pathogenesis of insulin resistance. No association was seen between POPs and glucose intolerance or markers of insulin resistance.
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