ArticlePloS one2008
Cytosolic sequestration of Prep1 influences early stages of T cell development.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Pbx1 as a regulator of T-cell fate in autoimmunity.Frontiers in immunology · 2026Review
- Lupus susceptibility geneScience advances · 2024Article
- Comprehensive summary: the role of PBX1 in development and cancers.Frontiers in cell and developmental biology · 2024Review
- The PBX1 lupus susceptibility gene regulates CD44 expression.Molecular immunology · 2017Article
- The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator.Genes and immunity · 2012Article
- Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of Pbx1 in T cells.Protein & cell · 2011Article
- Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.Molecular and cellular biology · 2011Article
- Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Genes and immunity · 2010Article
- An autoinhibitory effect of the homothorax domain of Meis2.The FEBS journal · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic mice. To further investigate the role of this homeodomain DNA-binding protein in T cell development, we generated transgenic mice expressing the N-terminal fragment of Pbx1 (Pbx1NT) under the control of the Lck proximal promoter. PRINCIPAL
findingsPbx1NT causes Prep1 cytosolic sequestration, abolishes Prep1-dependent DNA-binding activity and results in reduced Pbx2 expression in developing thymocytes. Transgenic thymi reveal increased numbers of CD4(-) CD8(-) CD44(-) (DN3 and DN4) thymocytes, due to a higher frequency of DN2 and DN4 Pbx1NT thymocytes in the S phase. Transgenic thymocytes however do not accumulate at later stages, as revealed by a normal representation of CD4/CD8 double positive and single positive thymocytes, due to a higher rate of apoptotic cell death of DN4 Pbx1NT thymocytes.
conclusionThe results obtained by genetic (Prep1 hypomorphic) and functional (Pbx1NT transgenic) inactivation of Prep1 support nonredundant roles for this homeodomain protein during different stages of T cell development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.