ArticlePloS one2008
Genomic content of Bordetella pertussis clinical isolates circulating in areas of intensive children vaccination.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2021Review
- Comparative genomics of whole-cell pertussis vaccine strains from India.BMC genomics · 2020Article
- Review
- Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis.Infection and immunity · 2018Article
- Bordetella pertussis evolution in the (functional) genomics era.Pathogens and disease · 2015Review
- Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.Scientific reports · 2015Article
- A Functional Tricarboxylic Acid Cycle Operates during Growth of Bordetella pertussis on Amino Acid Mixtures as Sole Carbon Substrates.PloS one · 2015Article
- Investigating genome reduction of Bordetella pertussis using a multiplex PCR-based reverse line blot assay (mPCR/RLB).BMC research notes · 2014Article
- Article
- Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the United States.Clinical and vaccine immunology : CVI · 2014Article
- Insertion sequences shared by Bordetella species and implications for the biological diagnosis of pertussis syndrome.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA.Microbiology (Reading, England) · 2012Review
- BpsR modulates Bordetella biofilm formation by negatively regulating the expression of the Bps polysaccharide.Journal of bacteriology · 2012Article
- Article
- Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan.PloS one · 2012Article
- Complete genome sequence of Bordetella pertussis CS, a Chinese pertussis vaccine strain.Journal of bacteriology · 2011Article
- The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in pediatric critical care medicine.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2011Review
- Article
- Article
- Immunoproteomic analysis of human serological antibody responses to vaccination with whole-cell pertussis vaccine (WCV).PloS one · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of the study was to analyse the evolution of Bordetella pertussis population and the influence of herd immunity in different areas of the world where newborns and infants are highly vaccinated. METHODOLOGY: The analysis was performed using DNA microarray on 15 isolates, PCR on 111 isolates as well as GS-FLX sequencing technology on 3 isolates and the B. pertussis reference strain, Tohama I. PRINCIPAL
findingsOur analyses demonstrate that the current circulating isolates are continuing to lose genetic material as compared to isolates circulating during the pre-vaccine era whatever the area of the world considered. The lost genetic material does not seem to be important for virulence. Our study confirms that the use of whole cell vaccines has led to the control of isolates that were similar to vaccine strains. GS-FLX sequencing technology shows that current isolates did not acquire any additional material when compared with vaccine strains or with isolates of the pre-vaccine era and that the sequenced strain Tohama I is not representative of the isolates. Furthermore, this technology allowed us to observe that the number of Insertion Sequence elements contained in the genome of the isolates is temporally increasing or varying between isolates.
conclusionsB. pertussis adaptation to humans is still in progress by losing genetic material via Insertion Sequence elements. Furthermore, recent isolates did not acquire any additional material when compared with vaccine strains or with isolates of the pre-vaccine era. Herd immunity, following intensive vaccination of infants and children with whole cell vaccines, has controlled isolates similar to the vaccine strains without modifying significantly the virulence of the isolates. With the replacement of whole cell vaccines by subunit vaccines, containing only few bacterial antigens targeting the virulence of the bacterium, one could hypothesize the circulation of isolates expressing less or modified vaccine antigens.
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