ArticlePloS one2008
Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
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- Screening and Identification of Key Biomarkers in Metastatic Uveal Melanoma: Evidence from a Bioinformatic Analysis.Journal of clinical medicine · 2022Article
- Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model.Journal of the American Society of Nephrology : JASN · 2021Article
- Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway.Development (Cambridge, England) · 2016Article
- Pathway analysis supports association of nonsyndromic cryptorchidism with genetic loci linked to cytoskeleton-dependent functions.Human reproduction (Oxford, England) · 2015Article
- DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines.BMC cancer · 2015Article
- Class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release, and antigen presentation via MHC class II.European journal of immunology · 2015Article
- Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate.Human molecular genetics · 2014Article
- Interaction between microtubules and the Drosophila formin Cappuccino and its effect on actin assembly.The Journal of biological chemistry · 2014Article
- An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.PloS one · 2014Article
- Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin.The Journal of biological chemistry · 2013Article
- Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons.PloS one · 2011Article
- A nucleator arms race: cellular control of actin assembly.Nature reviews. Molecular cell biology · 2010Review
- Formins in development: orchestrating body plan origami.Biochimica et biophysica acta · 2010Review
- Formins and microtubules.Biochimica et biophysica acta · 2010Review
- Unleashing formins to remodel the actin and microtubule cytoskeletons.Nature reviews. Molecular cell biology · 2010Review
- Formin1 disruption confers oligodactylism and alters Bmp signaling.Human molecular genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRegulation of the cytoskeleton is a central feature of cell migration. The formin family of proteins controls the rate of actin nucleation at its barbed end. Thus, formins are predicted to contribute to several important cell processes such as locomotion, membrane ruffling, vesicle endocytosis, and stress fiber formation and disassociation. METHODOLOGY/PRINCIPAL
findingsIn this study we investigated the functional role of Formin1-isoform4 (Fmn1-IV) by using genetically null primary cells that displayed augmented protrusive behaviour during wound healing and delayed cell spreading. Cells deficient of Fmn1-IV also showed reduced efficiency of focal adhesion formation. Additionally, we generated an enhanced green fluorescence protein (EGFP)-fused Fmn1-IV knock-in mouse to monitor the endogenous subcellular localization of Fmn1-IV. Its localization was found within the cytoplasm and along microtubules, yet it was largely excluded from adherens junctions. CONCLUSIONS/SIGNIFICANCE: It was determined that Fmn1-IV, as an actin nucleator, contributes to protrusion of the cell's leading edge and focal adhesion formation, thus contributing to cell motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.