Trial reportEnvironmental health perspectives2008
Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease.
Trial report in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies.Reviews on environmental health · 2012Pooled it
- Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10 and PM2.5.Environmental health perspectives · 2011Pooled it
- Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution.Environmental health perspectives · 2010Pooled it
- Cardiovascular effects of sub-daily levels of ambient fine particles: a systematic review.Environmental health : a global access science source · 2010Pooled it
- Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults.Environmental research · 2020Trial
- The effects of facemasks on airway inflammation and endothelial dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study.Particle and fibre toxicology · 2018Trial
- Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location.Environmental health perspectives · 2014Trial
- Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation.European heart journal · 2011Trial
- In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults.Environmental health perspectives · 2011Trial
- Vascular effects of ultrafine particles in persons with type 2 diabetes.Environmental health perspectives · 2010Trial
- Circulating endothelial progenitor cells are not affected by acute systemic inflammation.American journal of physiology. Heart and circulatory physiology · 2010Trial
- Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans.Hypertension (Dallas, Tex. : 1979) · 2009Trial
- Noise and Air Pollution as Risk Factors for Hypertension: Part II-Pathophysiologic Insight.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Noise and Air Pollution as Risk Factors for Hypertension: Part I-Epidemiology.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Causality of particulate matter on cardiovascular diseases and cardiovascular biomarkers.Frontiers in public health · 2023Article
- Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions.Particle and fibre toxicology · 2022Review
- Impact of ambient fine particulate matter on emergency department admissions for circulatory system disease in a city in Northeast China.Environmental science and pollution research international · 2021Article
- Exposure to urban particulate matter and its association with human health risks.Environmental science and pollution research international · 2020Review
- Oxidative stress pathways of air pollution mediated toxicity: Recent insights.Redox biology · 2020Review
- Roadside Exposure and Inflammation Biomarkers among a Cohort of Traffic Police in Kathmandu, Nepal.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundExposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans.
objectivesWe conducted a study to determine whether exposure to ambient particulate matter causes vascular dysfunction.
methodsTwelve male patients with stable coronary heart disease and 12 age-matched volunteers were exposed to concentrated ambient fine and ultrafine particles (CAPs) or filtered air for 2 hr using a randomized, double-blind cross-over study design. We measured peripheral vascular vasomotor and fibrinolytic function, and inflammatory variables-including circulating leukocytes, serum C-reactive protein, and exhaled breath 8-isoprostane and nitrotyrosine-6-8 hr after both exposures.
resultsParticulate concentrations (mean +/- SE) in the exposure chamber (190+/-37 microg/m(3)) were higher than ambient levels (31+/-8 microg/m(3)) and levels in filtered air (0.5+/-0.4 microg/m(3); p<0.001). Chemical analysis of CAPs identified low levels of elemental carbon. Exhaled breath 8-isoprostane concentrations increased after exposure to CAPs (16.9+/-8.5 vs. 4.9+/-1.2 pg/mL, p<0.05), but markers of systemic inflammation were largely unchanged. Although there was a dose-dependent increase in blood flow and plasma tissue plasminogen activator release (p<0.001 for all), CAPs exposure had no effect on vascular function in either group.
conclusionsDespite achieving marked increases in particulate matter, exposure to CAPs--low in combustion-derived particles--did not affect vasomotor or fibrinolytic function in either middle-aged healthy volunteers or patients with coronary heart disease. These findings contrast with previous exposures to dilute diesel exhaust and highlight the importance of particle composition in determining the vascular effects of particulate matter in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.