ArticlePloS one2008
Sexually antagonistic selection in human male homosexuality.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Evolution of Same-sex Sexual Behavior: Using Old Theory to Answer New Questions.Integrative and comparative biology · 2026Review
- Genetic variants underlying human bisexual behavior are reproductively advantageous.Science advances · 2024Article
- Male androphilia, fraternal birth order, and female fecundity in Samoa: A 10-y retrospective.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Direct Reproductive Cost of Same-Sex Attraction: Evidence from Two Nationally Representative U.S. Samples.Archives of sexual behavior · 2022Article
- Genomic evidence consistent with antagonistic pleiotropy may help explain the evolutionary maintenance of same-sex sexual behaviour in humans.Nature human behaviour · 2021Article
- More Evidence and Context Are Needed to Evaluate the Possibility That Scent Perception Is Part of the Same-Sex Sexual Behavior Story.Archives of sexual behavior · 2021Article
- Prosociality and a Sociosexual Hypothesis for the Evolution of Same-Sex Attraction in Humans.Frontiers in psychology · 2019Article
- Possible Balancing Selection in Human Female Homosexuality.Human nature (Hawthorne, N.Y.) · 2018Article
- A test of genetic models for the evolutionary maintenance of same-sex sexual behaviour.Proceedings. Biological sciences · 2015Article
- Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone.Evolutionary applications · 2015Review
- Human homosexuality: a paradigmatic arena for sexually antagonistic selection?Cold Spring Harbor perspectives in biology · 2015Review
- On the evolutionary origins of differences in sexual preferences.Frontiers in psychology · 2015Article
- Is sexual conflict an "engine of speciation"?Cold Spring Harbor perspectives in biology · 2014Review
- Constraints on the coevolution of contemporary human males and females.Proceedings. Biological sciences · 2012Article
- Fecundity of paternal and maternal non-parental female relatives of homosexual and heterosexual men.PloS one · 2012Article
- Sex is always well worth its two-fold cost.PloS one · 2009Article
- Sexually antagonistic "zygotic drive" of the sex chromosomes.PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of hypotheses have attempted to give an evolutionary explanation for the long-standing persistence of this trait, and for its asymmetric distribution in family lines; however a satisfactory understanding of the population genetics of male homosexuality is lacking at present. We perform a systematic mathematical analysis of the propagation and equilibrium of the putative genetic factors for male homosexuality in the population, based on the selection equation for one or two diallelic loci and Bayesian statistics for pedigree investigation. We show that only the two-locus genetic model with at least one locus on the X chromosome, and in which gene expression is sexually antagonistic (increasing female fitness but decreasing male fitness), accounts for all known empirical data. Our results help clarify the basic evolutionary dynamics of male homosexuality, establishing this as a clearly ascertained sexually antagonistic human trait.
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