ArticleInternational journal of obesity (2005)2008
Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents.
Article in International journal of obesity (2005), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children.Scientific reports · 2019Pooled it
- Effects of Nutrition Education Program for the Japan Diet on Serum Phospholipid Fatty Acid Compositions in Patients with Dyslipidemia: Re-analysis of Data from a Previous Randomized Controlled Trial.Journal of atherosclerosis and thrombosis · 2023Trial
- Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study.Lipids in health and disease · 2009Trial
- Association between mid-upper arm circumference and weight for height with long-term survival in South Kivu, eastern Democratic Republic of Congo: Lwiro cohort.BMC nutrition · 2026Article
- A vegan diet signature from a multi-omics study on different European populations is related to favorable metabolic outcomes.Gut microbes · 2025Observational
- Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet.Science signaling · 2025Article
- Serum dihomo-γ-linolenic acid concentration as a potential novel noninvasive biomarker for liver steatosis detection in children.Clinical and experimental hepatology · 2024Article
- Clinically relevant body composition phenotypes are associated with distinct circulating cytokine and metabolomic milieus in epithelial ovarian cancer patients.Frontiers in immunology · 2024Article
- Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity.Frontiers in nutrition · 2023Article
- Pediatric Population with Down Syndrome: Obesity and the Risk of Cardiovascular Disease and Their Assessment Using Omics Techniques-Review.Biomedicines · 2022Review
- Interplay between fatty acid desaturase2 (FADS2) rs174583 genetic variant and dietary antioxidant capacity: cardio-metabolic risk factors in obese individuals.BMC endocrine disorders · 2022Article
- Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study.Frontiers in nutrition · 2022Article
- The Interaction Between Fatty Acid Desaturase-2 (FADS2) rs174583 Genetic Variant and Dietary Quality Indices (DASH and MDS) Constructs Different Metabolic Phenotypes Among Obese Individuals.Frontiers in nutrition · 2021Article
- Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.Journal of atherosclerosis and thrombosis · 2020Article
- Plasma fatty acid profile is related to cognitive function in obese Chinese populations (35-64 years): A cross-sectional study.Food science & nutrition · 2020Article
- Fatty Acid Profile and Desaturase Activities in 7-10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure.International journal of molecular sciences · 2020Article
- Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.Gastroenterology research and practice · 2019Article
- Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population.International journal of molecular sciences · 2018Review
- Associations between fatty acids and low-grade inflammation in children from the LISAplus birth cohort study.European journal of clinical nutrition · 2017Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
aim/hypothesisThe objective of this study was to describe the relation of serum fatty acids and desaturase activity (DA) to overweight, insulin sensitivity and cardiovascular disease (CVD) risk factors in adolescents.
methodsThe relations of % serum phospholipid (PL) and cholesteryl ester (CE) fatty acids and estimated DA with CVD risk factors were examined in 264 adolescents (average age 15 years). Fatty acids were determined by gas liquid chromotography. Surrogate measures of DA were expressed as ratios of serum fatty acids: Delta9 DA=16:0/16:1; Delta6 DA=20:3,n6/18:2,n6 (PL) or 18:3,n6/18:2,n6 (CE); and Delta5 DA=20:4,n6/20:3,n6. Spearman partial correlations of fatty acids (%) and DA ratios with CVD risk factors were reported, adjusting for age, sex, race, Tanner stage, energy intake and physical activity.
resultsOverweight adolescents compared to normal weight had more adverse levels of CVD risk factors, composition of PL and CE fatty acids in serum, and Delta6 DA and Delta5 DA ratios. Linoleic acid was inversely related to body mass index (BMI), waist circumference and triglycerides (P<or=0.01). Dihomo-gamma-linolenic acid was positively related to BMI, waist, insulin, and triglycerides, and inversely related to high-density lipoprotein-cholesterol levels (P<or=0.01). Delta6 DA was adversely associated with most of the risk factors (P<or=0.01), whereas triglycerides and fasting insulin were beneficially related to Delta5 DA (P<or=0.01).
conclusionThese findings support those observed in adults, that factors, such as type of dietary fat, physical activity, and obesity, may influence fatty acid metabolism and are important in the development of adverse CVD risk factors as early as adolescence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.