Evidence map›Paper›PMID 18560338›Full record

ArticleMolecules (Basel, Switzerland)2008

The antioxidant response induced by Lonicera caerulaea berry extracts in animals bearing experimental solid tumors.

Maria Iuliana Gruia, Eliza Oprea, Ion Gruia, Valentina Negoita, Ileana Cornelia Farcasanu

Erratum issuedAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors.

Maria Iuliana GruiaInstitute of Oncology Bucharest, 252 Fundeni, 022338, Bucharest, Romania.
Eliza Oprea
Ion Gruia
Valentina Negoita
Ileana Cornelia Farcasanu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentally-induced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress.

Indexed as

AnimalsAntioxidantsCell ProliferationCeruloplasminDrug Screening Assays, AntitumorFruitLipid PeroxidationLoniceraMaleNeoplasms, ExperimentalOxidation-ReductionOxidative StressPhytotherapyPlant ExtractsRatsRats, WistarAntioxidantsCeruloplasminPlant ExtractsSulfhydryl Compounds

Identifiers

PMID18560338
PMCPMC6245305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.