SynthesisJournal of genetics2008
Novel non-HLA-susceptible regions determined by meta-analysis of four genomewide scans for ankylosing spondylitis.
Synthesis in Journal of genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of genome-wide linkage scans for renal function traits.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Pooled it
- Article
- Association Between Dentin Matrix Protein 1 (rs10019009) Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province.Chinese medical journal · 2016Article
- Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis.Rheumatology international · 2016Article
- Mannose-binding lectin 2 gene haplotype analysis in Korean patients with ankylosing spondylitis.Rheumatology international · 2012Article
- The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population.Rheumatology international · 2011Article
- Recent studies on the genetic basis of ankylosing spondylitis.Current rheumatology reports · 2009Review
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Authors and funding
4 authors.
Funding
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Abstract
We identified novel non-HLA-susceptible regions for ankylosing spondylitis (AS) by applying the genome-search-metaanalysis (GSMA) method to combine the previous four AS genomewide scan studies including 479 families with 1175 affected individuals. Three original genomescans were mainly analysed for Caucasian families and one analysed for Han Mongolian families. Ten bins had both Psumrnk and Pord <0.05, suggesting these bins most likely contain AS-linked loci. The 10 bins are 6.2, 16.3, 6.1, 3.3, 6.3, 16.4, 10.5, 17.1, 2.5 and 2.9. The most significant result of linkage was on chromosome 6p22.3-p21.1 (bin 6.2, Psumrnk <0.000417), where HLA loci are located. By addition of a genome scan of Chinese origin, our GSMA result further confirmed the HLA loci as the greatest susceptible region to AS and suggested that non-HLA loci chromosome 16q, 3p, 10q, 2p, 2q and 17p, may also contain AS-linked loci. The novel loci identified in our result give hints to further studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.