ArticleNeuro-oncology2008
Primary central nervous system lymphoma in Japan: changes in clinical features, treatment, and prognosis during 1985-2004.
Article in Neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Safety and efficacy of tisagenlecleucel in primary CNS lymphoma: a phase 1/2 clinical trial.Blood · 2022Trial
- Acute Presentation of Primary CNS Lymphoma Mimicking Toxoplasma in HIV Infection.Journal of community hospital internal medicine perspectives · 2023Article
- Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement.Brain tumor pathology · 2022Article
- Venous thromboembolism in primary central nervous system lymphoma during frontline chemoimmunotherapy.Research and practice in thrombosis and haemostasis · 2020Article
- Long-term outcomes of rituximab, temozolomide and high-dose methotrexate without consolidation therapy for lymphoma involving the CNS.International journal of hematologic oncology · 2017Article
- Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.The American journal of surgical pathology · 2015Article
- Primary CNS lymphoma treated with radiotherapy in Japan: a survey of patients treated in 2005-2009 and a comparison with those treated in 1985-2004.International journal of clinical oncology · 2014Article
- Radiation therapy for primary central nervous system lymphoma.Oncology reviews · 2013Review
- The potential role of Ku80 in primary central nervous system lymphoma as a prognostic factor.Contemporary oncology (Poznan, Poland) · 2013Article
- A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment.Case reports in radiology · 2013Article
- Treatment outcomes and survival in patients with primary central nervous system lymphomas treated between 1995 and 2010 - a single centre report.Radiology and oncology · 2012Article
- Prognosis of primary central nervous system lymphoma treated with radiotherapy alone.Japanese journal of radiology · 2012Article
- High dose methotrexate and extended hours high-flux hemodialysis for the treatment of primary central nervous system lymphoma in a patient with end stage renal disease.American journal of blood research · 2012Article
- Influence of Tumor Location on the Composition of Immune Infiltrate and Its Impact on Patient Survival. Lessons from DCBCL and Animal Models.Frontiers in immunology · 2012Article
- Primary CNS lymphoma other than DLBCL: a descriptive analysis of clinical features and treatment outcomes.Annals of hematology · 2011Article
- Survival among patients with primary central nervous system lymphoma, 1973-2004.Journal of neuro-oncology · 2011Article
- An atypical cause of trigeminal neuralgia and panhypopituitarism.The British journal of radiology · 2010Article
- Prognostic value of pretreatment 18F-FDG PET in patients with primary central nervous system lymphoma: SUV-based assessment.Journal of neuro-oncology · 2010Article
- Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy.Journal of neuro-oncology · 2010Article
- Primary intracranial lymphomas.Asian journal of neurosurgeryArticle
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16 authors.
Funding
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Abstract
We have conducted nationwide surveys of primary central nervous system lymphoma (PCNSL) treated since 1985. In the present study, we newly collected data between 2000 and 2004 and investigated changes in clinical features and outcome over time. A total of 739 patients with histologically proven PCNSL under going radiotherapy were analyzed. Seventeen institutions were surveyed, and data on 131 patients were collected. These data were compared with updated data that were previously obtained for 466 patients treated during 1985-1994 and 142 patients treated during 1995-1999. Recent trends toward decrease in male/female ratio, increase in aged patients, and increase in patients with multiple lesions were seen. Regarding treatment, decrease in attempts at surgical tumor removal and increases in use of systemic chemotherapy and methotrexate (MTX)-containing regimens were observed. The median survival time was 18, 29, and 24 months for patients seen during 1985-1994, 1995-1999, and 2000-2004, respectively, and the respective 5-year survival rates were 15%, 30%, and 30%. In groups seen during 1995-1999 and during 2000-2004, patients who received systemic or MTX-containing chemotherapy had better prognosis than those who did not. Multivariate analysis of all patients seen during 1985-2004 suggested the usefulness of MTX-containing chemotherapy as well as the importance of age, lactate dehydrogenase level, and tumor multiplicity as prognostic factors. Thus, this study revealed several notable changes in clinical features of PCNSL patients. The prognosis improved during the last 10 years. Advantage of radiation plus chemotherapy, especially MTX-containing chemotherapy, over radiation alone was suggested.
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