ReviewPhysiological genomics2008
Contemporary approaches for modifying the mouse genome.
Review in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort.Nature communications · 2025Article
- Assessing the Effectiveness of a Far-Red Fluorescent Reporter for Tracking Stem Cells In Vivo.International journal of molecular sciences · 2017Article
- Comparative transcriptomics in human and mouse.Nature reviews. Genetics · 2017Review
- The Convenience of Single Homology Arm Donor DNA and CRISPR/Cas9-Nickase for Targeted Insertion of Long DNA Fragment.Cell journal · 2017Article
- Heterogeneous Stock Populations for Analysis of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Fully integrated reflection-mode photoacoustic, two-photon, and second harmonic generation microscopy in vivo.Scientific reports · 2016Article
- QTL mapping in outbred populations: successes and challenges.Physiological genomics · 2014Review
- Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice.PloS one · 2014Article
- Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.PloS one · 2014Article
- Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.Neuron · 2013Article
- Multimodal photoacoustic ophthalmoscopy in mouse.Journal of biophotonics · 2013Article
- Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1α in zebrafish.Pharmacology, biochemistry, and behavior · 2012Article
- Small fragment homologous replacement: evaluation of factors influencing modification efficiency in an eukaryotic assay system.PloS one · 2012Article
- The mouse genetics toolkit: revealing function and mechanism.Genome biology · 2011Review
- Engineering the embryo.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genetics of circadian rhythms in Mammalian model organisms.Advances in genetics · 2011Review
- Production of p53 gene knockout rats by homologous recombination in embryonic stem cells.Nature · 2010Article
- Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project.Plant physiology · 2010Article
- Next-generation sequencing of vertebrate experimental organisms.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The mouse is a premiere experimental organism that has contributed significantly to our understanding of vertebrate biology. Manipulation of the mouse genome via embryonic stem (ES) cell technology makes it possible to engineer an almost limitless repertoire of mutations to model human disease and assess gene function. In this review we outline recent advances in mouse experimental genetics and provide a "how-to" guide for those people wishing to access this technology. We also discuss new technologies, such as transposon-mediated mutagenesis, and resources of targeting vectors and ES cells, which are likely to dramatically accelerate the pace with which we can assess gene function in vivo, and the progress of forward and reverse genetic screens in mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.