ArticleProceedings of the National Academy of Sciences of the United States of America2008
Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 379 citations in OpenAlex.
- Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men.Molecular genetics & genomic medicine · 2019Trial
- Functionalized Carbon Nanoparticles as Theranostic Agents and Their Future Clinical Utility in Oncology.Bioengineering (Basel, Switzerland) · 2023Review
- Carbon-Based Stimuli-Responsive Nanomaterials: Classification and Application.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Carbon nanomaterials for phototherapy.Nanophotonics (Berlin, Germany) · 2022Review
- Supramolecular Combination Cancer Therapy Based on Macrocyclic Supramolecular Materials.Polymers · 2022Review
- Recent Insights into NIR-Light-Responsive Materials for Photothermal Cell Treatments.Nanomaterials (Basel, Switzerland) · 2022Review
- Review
- Nanoparticle-Induced Airway Eosinophilia Is Independent of ILC2 Signaling but Associated With Sex Differences in Macrophage Phenotype Development.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Recent Insights and Multifactorial Applications of Carbon Nanotubes.Micromachines · 2021Review
- Current Advances in Black Phosphorus-Based Drug Delivery Systems for Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Optimization of Mass Flow in the Synthesis of Ferromagnetic Carbon Nanotubes in Chemical Vapor Deposition System.Materials (Basel, Switzerland) · 2021Article
- A technique to measure respirator protection factors against aerosol particles in simulated workplace settings using portable instruments.Journal of occupational and environmental hygiene · 2020Article
- Encapsulation for Cancer Therapy.Molecules (Basel, Switzerland) · 2020Review
- Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Clinical Cancer Nanomedicine.Nano today · 2019Article
- Terahertz Reflectometry Imaging of Carbon Nanomaterials for Biological Application.Journal of nanomedicine & nanotechnology · 2019Article
- Performance Comparison of Field Portable Instruments to the Scanning Mobility Particle Sizer Using Monodispersed and Polydispersed Sodium Chloride Aerosols.Annals of work exposures and health · 2018Article
- Magnetic carbon nanotubes for self-regulating temperature hyperthermia.RSC advances · 2018Article
- Mesoporous Carbon Nanospheres as a Multifunctional Carrier for Cancer Theranostics.Theranostics · 2018Article
- Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes.International journal of nanomedicine · 2017Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Single-walled carbon nanotubes (CNTs) emit heat when they absorb energy from near-infrared (NIR) light. Tissue is relatively transparent to NIR, which suggests that targeting CNTs to tumor cells, followed by noninvasive exposure to NIR light, will ablate tumors within the range of NIR. In this study, we demonstrate the specific binding of antibody-coupled CNTs to tumor cells in vitro, followed by their highly specific ablation with NIR light. Biotinylated polar lipids were used to prepare stable, biocompatible, noncytotoxic CNT dispersions that were then attached to one of two different neutralite avidin-derivatized mAbs directed against either human CD22 or CD25. CD22(+)CD25(-) Daudi cells bound only CNTs coupled to the anti-CD22 mAb; CD22(-)CD25(+) activated peripheral blood mononuclear cells bound only to the CNTs coupled to the anti-CD25 mAb. Most importantly, only the specifically targeted cells were killed after exposure to NIR light.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.