ArticleDiabetes2008
High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Meta-Analysis and Bioinformatics Detection of Susceptibility Genes in Diabetic Nephropathy.International journal of molecular sciences · 2021Pooled it
- Pooled it
- Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study.International journal of molecular sciences · 2024Article
- Genetic and epigenetic background of diabetic kidney disease.Frontiers in endocrinology · 2023Review
- Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes.Diabetes · 2021Article
- Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B.Scientific reports · 2020Article
- Recent progress in the genetics of diabetic microvascular complications.World journal of diabetes · 2015Review
- Human genetics of diabetic vascular complications.Journal of genetics · 2013Review
- HLA class I and II alleles are associated with microvascular complications of type 1 diabetes.Human immunology · 2013Article
- Does familial clustering of risk factors for long-term diabetic complications leave any place for genes that act independently?Journal of cardiovascular translational research · 2012Review
- A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype.PloS one · 2012Article
- Refined mapping of the renal failure RF-3 quantitative trait locus.Journal of the American Society of Nephrology : JASN · 2011Article
- TGF-alpha mediates genetic susceptibility to chronic kidney disease.Journal of the American Society of Nephrology : JASN · 2011Article
- Article
- Uncovering genes and regulatory pathways related to urinary albumin excretion.Journal of the American Society of Nephrology : JASN · 2011Article
- Successes achieved and challenges ahead in translating biomarkers into clinical applications.The AAPS journal · 2010Article
- Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.BMC medical genomics · 2010Article
- Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.BMC medical genetics · 2010Article
- Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus.Seminars in nephrology · 2010Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 4 countries.
Funding
Abstract
objectiveEpidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND
methodsTo efficiently search for genomic regions harboring diabetic nephropathy genes, we conducted a scan using 5,382 informative single nucleotide polymorphisms on 100 sibpairs concordant for type 1 diabetes but discordant for diabetic nephropathy. In addition to being powerful for detecting linkage to diabetic nephropathy, this design allows linkage analysis on type 1 diabetes via traditional affected sibpair (ASP) analysis. In weighing the evidence for linkage, we considered maximum logarithm of odds score (maximum likelihood score [MLS]) values and corresponding allelic sharing patterns, calculated and viewed graphically using the software package SPLAT.
resultsOur primary finding for diabetic nephropathy, broadly defined, is on chromosome 19q (MLS = 3.1), and a secondary peak exists on chromosome 2q (MLS = 2.1). Stratification of discordant sibpairs based on whether disease had progressed to ESRD suggested four tertiary peaks on chromosome 1q (ESRD only), chromosome 20p (proteinuria only), and chromosome 3q (two loci 58 cm apart, one for ESRD only and another for proteinuria only). Additionally, analysis of 130 ASPs for type 1 diabetes confirmed the linkage to the HLA region on chromosome 6p (MLS = 9.2) and IDDM15 on chromosome 6q (MLS = 3.1).
conclusionsThis study identified several novel loci as candidates for diabetic nephropathy, none of which appear to be the sole genetic determinant of diabetic nephropathy in type 1 diabetes. In addition, this study confirms two previously reported type 1 diabetes loci.
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