ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2008
Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.The Journal of experimental medicine · 2022Article
- The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status.Pharmaceutics · 2021Article
- Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis.Experimental gerontology · 2021Review
- Article
- DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity.Scientific reports · 2020Article
- Analysis of Transcriptome and miRNAome in the Muscle of Bamei Pigs at Different Developmental Stages.Animals : an open access journal from MDPI · 2020Article
- Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.Journal of cachexia, sarcopenia and muscle · 2020Article
- Concurrent EPA and DHA Supplementation Impairs Brown Adipogenesis of C2C12 Cells.Frontiers in genetics · 2020Article
- Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans.Journal of visualized experiments : JoVE · 2017Article
- Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy.Cell stem cell · 2017Article
- Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise.Aging cell · 2016Review
- Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice.Human molecular genetics · 2015Article
- Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.Aging cell · 2015Review
- A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.Science translational medicine · 2014Article
- Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice.EMBO molecular medicine · 2013Article
- Automated image analysis of skeletal muscle fiber cross-sectional area.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model.European cells & materials · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We report an age-dependent increase in nonimmunohematopoietic cells (CD45neg) in regenerating muscle characterized by high stem-cell antigen (Sca-1) expression. In aged regenerating muscle, only 14% of these CD45negSca-1pos cells express MyoD, whereas 82% of CD45negSca-1(pos) cells are MyoDpos in young adult muscle. In vitro, CD45negMyoDnegSca-1pos cells overexpress fibrosis-promoting genes, potentially controlled by Wnt2. The cells are proliferative, nonmyogenic, and nonadipogenic, and arise in clonally derived myoblast cultures from aged mice. MyoDneg Sca-1pos nonmyogenic cells also emerge in C2C12 myoblast cultures at late passage. Both in vitro and in vivo studies suggest that MyoDnegSca-1pos cells from aged muscle are more susceptible to apoptosis than myoblasts, which may contribute to depletion of the satellite cell pool. Thus, with age, a subset of myoblasts takes on an altered phenotype, which is marked by high Sca-1 expression. These cells do not participate in muscle regeneration, and instead may contribute to muscle fibrosis in aged muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.