ArticleGenes & development2008
Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- An Evolutionary Perspective on Yeast Mating-Type Switching.Genetics · 2017Review
- Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.Nucleic acids research · 2016Article
- Article
- Genome-wide analysis of functional sirtuin chromatin targets in yeast.Genome biology · 2013Article
- Comparative gene expression between two yeast species.BMC genomics · 2013Article
- Evolutionary role of interspecies hybridization and genetic exchanges in yeasts.Microbiology and molecular biology reviews : MMBR · 2012Review
- Evolutionary analysis of heterochromatin protein compatibility by interspecies complementation in Saccharomyces.Genetics · 2012Article
- Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms.PLoS genetics · 2012Article
- The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2012Review
- Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation.Nucleic acids research · 2012Article
- Reinventing heterochromatin in budding yeasts: Sir2 and the origin recognition complex take center stage.Eukaryotic cell · 2011Review
- The duplicated deacetylases Sir2 and Hst1 subfunctionalized by acquiring complementary inactivating mutations.Molecular and cellular biology · 2011Article
- A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Genetics · 2011Article
- The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus.G3 (Bethesda, Md.) · 2011Article
- Co-evolution of transcriptional silencing proteins and the DNA elements specifying their assembly.PLoS biology · 2010Article
- Polygenic and directional regulatory evolution across pathways in Saccharomyces.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- N-terminal acetylation of cellular proteins creates specific degradation signals.Science (New York, N.Y.) · 2010Article
- The Sir2-Sum1 complex represses transcription using both promoter-specific and long-range mechanisms to regulate cell identity and sexual cycle in the yeast Kluyveromyces lactis.PLoS genetics · 2009Article
- Article
- The Ime2 protein kinase enhances the disassociation of the Sum1 repressor from middle meiotic promoters.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mating-type determination circuit in Saccharomyces yeast serves as a classic paradigm for the genetic control of cell type in all eukaryotes. Using comparative genetics, we discovered a central and conserved, yet previously undetected, component of this genetic circuit: active repression of alpha-specific genes in a cells. Upon inactivation of the SUM1 gene in Saccharomyces bayanus, a close relative of Saccharomyces cerevisiae, a cells acquired mating characteristics of alpha cells and displayed autocrine activation of their mating response pathway. Sum1 protein bound to the promoters of alpha-specific genes, repressing their transcription. In contrast to the standard model, alpha1 was important but not required for alpha-specific gene activation and mating of alpha cells in the absence of Sum1. Neither Sum1 protein expression, nor its association with target promoters was mating-type-regulated. Thus, the alpha1/Mcm1 coactivators did not overcome repression by occluding Sum1 binding to DNA. Surprisingly, the mating-type regulatory function of Sum1 was conserved in S. cerevisiae. We suggest that a comprehensive understanding of some genetic pathways may be best attained through the expanded phenotypic space provided by study of those pathways in multiple related organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.