Evidence map›Paper›PMID 18559471›Full record

ArticleGenes & development2008

Intriguing parasites and intramembrane proteases.

Robert B Rawson

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Frontiers in immunology · 2021
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Robert B RawsonDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Rob.Rawson@UTSouthwestern.Edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhomboid intramembrane proteases occur throughout the kingdoms of life. In this issue of Genes & Development, Baxt and colleagues (pp. 1636-1646) report that the single proteolytic rhomboid (EhROM1) from Entamoeba histolytica cleaves cell surface galactose-binding or N-acetylgalactosamine-binding (Gal/Gal-NAc) lectins. EhROM1 and lectins colocalize during phagocytosis and receptor capping. EhROM1 is found at the base of the cap rather than in the cap proper, suggesting a role in receptor shedding and implying that EhROM1 is crucial for amoebal infection.

Indexed as

Amyloid Precursor Protein SecretasesAnimalsAntigens, SurfaceEntamoeba histolyticaEntamoebiasisErbB ReceptorsHost-Parasite InteractionsHumansLife Cycle StagesMembrane ProteinsMetalloendopeptidasesModels, BiologicalPeptide HydrolasesProtein Processing, Post-TranslationalSerine EndopeptidasesAmyloid Precursor Protein SecretasesAntigens, SurfaceErbB ReceptorsMBTPS2 protein, humanMembrane ProteinsMetalloendopeptidasesPeptide HydrolasesRHBDF1 protein, humanSerine Endopeptidasestype I signal peptidase

Identifiers

PMID18559471
PMCPMC2732417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.