ArticleJournal of translational medicine2008
Translational medicine: science or wishful thinking?
Article in Journal of translational medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 77 citations in OpenAlex.
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- The importance of shared meaning-making for sustainable knowledge translation and health literacy.Journal of evaluation in clinical practice · 2022Article
- Development of an Interoperable and Easily Transferable Clinical Decision Support System Deployment Platform: System Design and Development Study.Journal of medical Internet research · 2022Article
- Nanofat: A therapeutic paradigm in regenerative medicine.World journal of stem cells · 2021Review
- Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood-Brain Barrier Alterations.Biomolecules · 2021Review
- Network construction of aberrantly expressed miRNAs and their target mRNAs in ventricular myocardium with ischemia-reperfusion arrhythmias.Journal of cardiothoracic surgery · 2020Article
- Towards a translational medical humanities: introducing the cultural crossings of care.Medical humanities · 2020Article
- The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach.Journal of translational medicine · 2020Article
- Article
- Clinical Predictive Modeling Development and Deployment through FHIR Web Services.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2015Article
- Preclinical PK/PD modeling and human efficacious dose projection for a glucokinase activator in the treatment of diabetes.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Identifying translational science within the triangle of biomedicine.Journal of translational medicine · 2013Article
- Translational research policies: disruptions and continuities in biomedical innovation systems in Austria, Finland and Germany.Journal of community genetics · 2013Article
- Close to the bench as well as at the bedside: involving service users in all phases of translational research.Health expectations : an international journal of public participation in health care and health policy · 2012Review
- A road map to Translational Medicine in Qatar and a model for the world.Journal of translational medicine · 2012Review
- Tracking the impact of translational research in psychiatry: state of the art and perspectives.Journal of translational medicine · 2012Article
- Chinese integrative medicine: translation toward person-centered and balanced medicine.Chinese journal of integrative medicine · 2012Review
- Transgenic pigs as models for translational biomedical research.Journal of molecular medicine (Berlin, Germany) · 2010Review
- Distinguishing between primary endocervical and endometrial adenocarcinomas: is a 2-marker (Vim/CEA) panel enough?Virchows Archiv : an international journal of pathology · 2010Article
- Turning laboratory findings into therapy: a marathon goal that has to be reached.Polskie Archiwum Medycyny Wewnetrznej · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Translational medicine" as a fashionable term is being increasingly used to describe the wish of biomedical researchers to ultimately help patients. Despite increased efforts and investments into R&D, the output of novel medicines has been declining dramatically over the past years. Improvement of translation is thought to become a remedy as one of the reasons for this widening gap between input and output is the difficult transition between preclinical ("basic") and clinical stages in the R&D process. Animal experiments, test tube analyses and early human trials do simply not reflect the patient situation well enough to reliably predict efficacy and safety of a novel compound or device. This goal, however, can only be achieved if the translational processes are scientifically backed up by robust methods some of which still need to be developed. This mainly relates to biomarker development and predictivity assessment, biostatistical methods, smart and accelerated early human study designs and decision algorithms among other features. It is therefore claimed that a new science needs to be developed called 'translational science in medicine'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.