ArticleBMJ (Clinical research ed.)2008
Long term prognosis in preschool children with wheeze: longitudinal postal questionnaire study 1993-2004.
Article in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01144910 (A Prospective, Open Label, Single-center Study of the Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Open Label, Single-center Study of the Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children.
Who cites it
12 citing papers in PubMed.
- Individual risk assessment tool for school-age asthma prediction in UK birth cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature.Journal of asthma and allergy · 2017Article
- Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score.Primary care respiratory journal : journal of the General Practice Airways Group · 2014Article
- Severe eczema in infancy can predict asthma development. A prospective study to the age of 10 years.PloS one · 2014Article
- Pediatric exercise-induced bronchoconstriction: contemporary developments in epidemiology, pathogenesis, presentation, diagnosis, and therapy.Current allergy and asthma reports · 2013Review
- Role of cells and mediators in exercise-induced bronchoconstriction.Immunology and allergy clinics of North America · 2013Review
- Epithelial regulation of eicosanoid production in asthma.Pulmonary pharmacology & therapeutics · 2012Review
- New insights into pathogenesis of exercise-induced bronchoconstriction.Current opinion in allergy and clinical immunology · 2012Review
- Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma.Psychosomatic medicine · 2011Article
- Determinants in early life for asthma development.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2009Article
- Asthma in preschool children: the next challenge.Current opinion in allergy and clinical immunology · 2009Review
- Wheeze in preschool children.BMJ (Clinical research ed.) · 2008Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo follow a population of preschool children with and without parent reported wheeze over a period of 6-11 years to determine prognosis and its important predictive factors.
designLongitudinal series of five postal surveys based on the international study of asthma and allergies in childhood questionnaire carried out between 1993 and 2004.
settingTwo general practice populations, south Manchester.
participants628 children aged less than 5 years at recruitment and those with at least six years' follow-up data.
main outcome measuresParent completed questionnaire data for respiratory symptoms and associated features.
resultsOf 628 children included in the study, 201 (32%) had parent reported wheeze at the first observation (baseline), of whom 27% also reported the symptom on the second occasion (persistent asthma). The only important baseline predictors of persistent asthma were exercise induced wheeze (odds ratio 3.94, 95% confidence interval 1.72 to 9.00) and a history of atopic disorders (4.44, 1.94 to 10.13). The presence of both predictors indicated a likelihood of 53.2% of developing asthma; if only one feature was present this decreased to 17.2%, whereas if neither was present the likelihood was 10.9%. Family history of asthma was not predictive of persistent asthma among children with preschool wheeze.
conclusionUsing two simple predictive factors (baseline parent reported exercise induced wheeze and a history of atopic disorders), it is possible to estimate the likelihood of future asthma in children presenting with preschool wheeze. The absence of baseline exercise induced wheeze and a history of atopic disorders reduces the likelihood of subsequent asthma by a factor of five.
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