ArticlePediatrics2008
Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing.
Article in Pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- The role of theERJ open research · 2025Article
- BPediatric research · 2018Article
- Gestational diabetes is associated with changes in placental microbiota and microbiome.Pediatric research · 2016Article
- Maternal smoking in pregnancy and its influence on childhood asthma.ERJ open research · 2016Review
- Secondhand Smoke Exposure and Depressive Symptoms among Korean Adolescents: JS High School Study.PloS one · 2016Article
- Association between second-hand smoke and psychological well-being amongst non-smoking wageworkers in Republic of Korea.Annals of occupational and environmental medicine · 2016Article
- Fetal lung and placental methylation is associated with in utero nicotine exposure.Epigenetics · 2014Article
- Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.Epigenetics · 2014Article
- The genomic origins of asthma.Thorax · 2014Review
- Observational
- Exploring the origins of asthma: Lessons from twin studies.European clinical respiratory journal · 2014Article
- Maternal infection in pregnancy and risk of asthma in offspring.Maternal and child health journal · 2013Article
- Association of tobacco smoke exposure and atopic sensitization.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Early life influences on the development of chronic obstructive pulmonary disease.Therapeutic advances in respiratory disease · 2013Review
- Asthma in Mexican school-age children is not associated with passive smoking or obesity.Asia Pacific allergy · 2013Article
- Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches.Human heredity · 2012Article
- Perinatal gene-gene and gene-environment interactions on IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Different implications of paternal and maternal atopy for perinatal IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Early postnatal exposure of mice to side-steam tobacco smoke increases neuropeptide Y in lung.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAssociations between single-nucleotide polymorphisms in the beta2-adrenergic receptor gene and asthma and wheeze have been inconsistent. Recent studies indicated that tobacco smoke affects beta2-adrenergic receptor gene expression and associations of beta2-adrenergic receptor gene variants with asthma in adults. We aimed to investigate the joint effects of in utero and childhood secondhand tobacco smoke exposure and 2 well-characterized functional single-nucleotide polymorphisms (Arg16Gly and Glu27Gln) of beta2-adrenergic receptor gene on asthma and wheezing in 3128 non-Hispanic and Hispanic white children of the Children's Health Study.
methodsWe fitted logistic regression models to estimate odds ratios and 95% confidence intervals for the independent and joint effects of these single-nucleotide polymorphisms and in utero and secondhand tobacco smoke exposure on asthma and wheeze outcomes.
resultsExposures to in utero maternal smoking and secondhand tobacco smoke were associated with wheezing. Children who were homozygous for the Arg16 allele and were exposed to maternal smoking in utero were at a threefold increased risk for lifetime wheeze compared with children who were unexposed and had at least 1 Gly16 allele. We found similar joint effects of secondhand tobacco smoke and Arg16Gly with wheezing. The risk for lifetime, current, and nocturnal wheeze increased with the number of smokers at home among Arg16 homozygous children. The results were consistent in 2 cohorts of children recruited in 1993 and 1996. Diplotype-based analyses were consistent with the single-nucleotide polymorphism-specific results. No associations were found for Glu27Gln.
conclusionsBoth in utero and childhood exposure to tobacco smoke were associated with an increased risk for wheeze in children, and the risks were greater for children with the Arg16Arg genotype or 2 copies of the Arg16-Gln27 diplotype. Exposures to smoking need to be taken into account when evaluating the effects of beta2-adrenergic receptor gene variants on respiratory health outcomes.
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