ArticleAutonomic neuroscience : basic & clinical2008
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
Article in Autonomic neuroscience : basic & clinical, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 71 citations in OpenAlex.
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- Molecular and cellular neurocardiology in heart disease.The Journal of physiology · 2025Review
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Neuroanatomy of spinal nociception and pain in dogs and cats: a practical review for the veterinary clinician.Frontiers in veterinary science · 2025Review
- The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine.Seminars in cell & developmental biology · 2024Review
- Distribution and morphology of calcitonin gene-related peptide (CGRP) innervation in flat mounts of whole rat atria and ventricles.Autonomic neuroscience : basic & clinical · 2024Article
- Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post-Myocardial Infarction.JACC. Basic to translational science · 2023Article
- Topographical organization and morphology of substance P (SP)-immunoreactive axons in the whole stomach of mice.The Journal of comparative neurology · 2023Article
- The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.Scientific reports · 2022Article
- Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia.JCI insight · 2022Article
- Neurohumoral Cardiac Regulation: Optogenetics Gets Into the Groove.Frontiers in physiology · 2021Review
- Anatomical evidence of non-parasympathetic cardiac nitrergic nerve fibres in rat.Journal of anatomy · 2021Article
- Spinal cord neural network interactions: implications for sympathetic control of the porcine heart.American journal of physiology. Heart and circulatory physiology · 2020Article
- Autonomic Modulation for Cardiovascular Disease.Frontiers in physiology · 2020Review
- Thoracic spinal cord neuromodulation obtunds dorsal root ganglion afferent neuronal transduction of the ischemic ventricle.American journal of physiology. Heart and circulatory physiology · 2019Article
- Autonomic Nervous System Dysfunction: JACC Focus Seminar.Journal of the American College of Cardiology · 2019Review
- Heart Rate Variability and Vagus Nerve Stimulation in Epilepsy Patients.Translational neuroscience · 2019Article
- Expression of oxytocin receptor in the rat superior cervical ganglion after myocardial infarction.International journal of clinical and experimental pathology · 2018Article
- Baicalin Depresses the Sympathoexcitatory Reflex Induced by Myocardial Ischemia via the Dorsal Root Ganglia.Frontiers in physiology · 2018Article
- Characterization of glutamatergic neurons in the rat atrial intrinsic cardiac ganglia that project to the cardiac ventricular wall.Neuroscience · 2016Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
While much is known about the influence of ventricular afferent neurons on cardiovascular function in the dog, identification of the neurochemicals transmitting cardiac afferent signals to central neurons is lacking. Accordingly, we identified ventricular afferent neurons in canine dorsal root ganglia (DRG) and nodose ganglia by retrograde labeling after injecting horseradish peroxidase (HRP) into the anterior right and left ventricles. Primary antibodies from three host species were used in immunohistochemical experiments to simultaneously evaluate afferent somata for the presence of HRP and markers for two neurotransmitters. Only a small percentage (2%) of afferent somata were labeled with HRP. About half of the HRP-identified ventricular afferent neurons in T(3) DRG also stained for substance P (SP), calcitonin gene-related peptide (CGRP), or neuronal nitric oxide synthase (nNOS), either alone or with two markers colocalized. Ventricular afferent neurons and the general population of T(3) DRG neurons showed the same labeling profiles; CGRP (alone or colocalized with SP) being the most common (30-40% of ventricular afferent somata in T(3) DRG). About 30% of the ventricular afferent neurons in T(2) DRG displayed CGRP immunoreactivity and binding of the putative nociceptive marker IB(4). Ventricular afferent neurons of the nodose ganglia were distinct from those in the DRG by having smaller size and lacking immunoreactivity for SP, CGRP, and nNOS. These findings suggest that ventricular sensory information is transferred to the central nervous system by relatively small populations of vagal and spinal afferent neurons and that spinal afferents use a variety of neurotransmitters.
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