Evidence map›Paper›PMID 18558465›Full record

ArticleAddictive behaviors2008

Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders.

Albert J Arias, Joel Gelernter, Grace Chan, Roger D Weiss, Kathleen T Brady, Lindsay Farrer, Henry R Kranzler

2 registry-linked trialsAbstract readMulticenter Study
In one paragraph

Article in Addictive behaviors, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01431235 nacompletednot on this mapstarted 2011, after this paper: background citation

Investigating the Efficacy of Cognitive Behavioral Therapy in Patients With Substance Use Disorder and Comorbid ADHD. A Randomized Controlled Trial With Cognitive Behavioral Therapy

TypeinterventionalSponsorArkinRan2011 to 2016Enrolled184ConditionsAttention Deficit Hyperactivity Disorder, Substance Use DisordersArmscognitive behavioral therapy for treating ADHD symptoms
NCT02477280 phase4completednot on this mapstarted 2016, after this paper: background citation

Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD and Substance Use Disorder

TypeinterventionalSponsorRegion VästmanlandRan2016 to 2021Enrolled39ConditionsAttention Deficit Hyperactivity Disorder, Substance Use DisorderArmsMethylphenidate, Placebo
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 208 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Albert J AriasDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA. arias@psychiatry.uchc.edu
Joel Gelernter
Grace Chan
Roger D Weiss
Kathleen T Brady
Lindsay Farrer
Henry R Kranzler
Boston University · USMcLean Hospital · USMedical University of South Carolina · USUConn Health · USVA Connecticut Healthcare System · US

Funding

Vulnerabilities for coping-related drinking among post-college young adultsP60AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI PETRY, NANCY M · 2008 to 2017
$17.5M
Sex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0M
WHO COLLABORATIVE PROJECT ON MANAGEMENT OF HARMFUL ALCOHOL CONSUMPTIONP50AA003510 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M · 1985 to 2007
$13.6M
GENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5M
Genetics of Cocaine DependenceR01DA018432 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 2006 to 2010
$3.5M
Novel Approaches to Alcoholism Pharmacotherapy and RiskK24AA013736 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD · 2002 to 2012
$1.5M
Approaches to the Genetics of Substance DependenceK24DA015105 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2003 to 2007
$603k
NIAAA NIH HHS AA03510NIAAA NIH HHS AA13736NIAAA NIH HHS K24 AA013736NIAAA NIH HHS P50 AA003510NIDA NIH HHS DA12690NIDA NIH HHS DA12849NIDA NIH HHS DA15105NIDA NIH HHS K24 DA015105NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA018432
6 · The paper itself

Abstract

unlabelledWe examined the prevalence and course of psychiatric and substance dependence (SD) disorders in subjects with SD and attention deficit hyperactivity disorder (ADHD).

methodWe interviewed 1761 adults with a lifetime diagnosis of cocaine and/or opioid dependence using the Semi-Structured Assessment for Drug Dependence and Alcoholism. Generalized linear regression with generalized estimating equation analysis was used to examine the associations between a lifetime diagnosis of ADHD and indicators of clinical course, and to identify unique correlates of ADHD.

resultsLifetime ADHD prevalence in the SD sample was 5.22% (vs. 0.85% in a group of individuals without SD). ADHD was associated with an earlier age of first substance use, more SD and psychiatric diagnoses, a greater likelihood of attempted suicide, and more hospitalizations. After controlling for conduct disorder, there were unique effects of ADHD on age of first substance use and number of SD diagnoses.

conclusionIn subjects with cocaine or opioid dependence, ADHD is associated with greater SD and psychiatric comorbidity and a more severe course of illness.

Indexed as

AdultAttention Deficit Disorder with HyperactivityChild, PreschoolCocaine-Related DisordersDiagnosis, Dual (Psychiatry)FemaleHumansImpulsive BehaviorMaleNuclear FamilyOpioid-Related DisordersPrevalenceRegression Analysis

Identifiers

PMID18558465
PMCPMC2532519
OpenAlexW2097422242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.