Evidence map›Paper›PMID 18558434›Full record

ReviewPharmacology & therapeutics2008

Synthesis, trafficking, and localization of muscarinic acetylcholine receptors.

Neil M Nathanson

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Downstream Signaling of Muscarinic MPharmacology research & perspectives · 2025
    Article
  6. Protective role of MJournal of molecular medicine (Berlin, Germany) · 2024
    Article
  7. Article
  8. The Cholinergic Brain in Parkinson's Disease.Movement disorders clinical practice · 2021
    Review
  9. Article
  10. Review
  11. Advances in CaExperimental and therapeutic medicine · 2020
    Review
  12. Article
  13. The role of GαBiochemistry and biophysics reports · 2018
    Article
  14. Article
  15. Evidence for MNeuroscience · 2017
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Neil M NathansonDepartment of Pharmacology, School of Medicine, University of Washington, Box 357750, Seattle, WA 98195-7750, USA. nathanso@u.washington.edu
University of Washington · US

Funding

Structural analysis of cardiac signal transduction proteinsP01HL044948 · NHLBI · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 1991 to 2005
$10.5M
MOLECULAR ANALYSIS OF NEURAL MUSCARINIC RECEPTORSR01NS026920 · NINDS · UNIVERSITY OF WASHINGTON · PI NATHANSON, NEIL MARC · 1989 to 2005
$1.8M
REGULATION OF MAMMALIAN CARDIAC MUSCARINIC RECEPTORSR01HL058676 · NHLBI · UNIVERSITY OF WASHINGTON · PI NATHANSON, NEIL MARC · 1998 to 2001
$411k
REGULATION OF MUSCARINIC CHOLINERGIC RECEPTORS IN HEARTR01HL030639 · NHLBI · UNIVERSITY OF WASHINGTON · PI NATHANSON, NEIL MARC · 1985 to 2000
$232k
NHLBI NIH HHS P01 HL044948NHLBI NIH HHS R01 HL030639NHLBI NIH HHS R01 HL058676NINDS NIH HHS R01 NS026920
6 · The paper itself

Abstract

Muscarinic acetylcholine receptors are members of the G-protein coupled receptor superfamily that are expressed in and regulate the function of neurons, cardiac and smooth muscle, glands, and many other cell types and tissues. The correct trafficking of membrane proteins to the cell surface and their subsequent localization at appropriate sites in polarized cells are required for normal cellular signaling and physiological responses. This review will summarize work on the synthesis and trafficking of muscarinic receptors to the plasma membrane and their localization at the cell surface.

Indexed as

AnimalsBrainGlycosylationHumansIntestinal MucosaKidneyMembrane ProteinsOocytesProtein TransportReceptors, MuscarinicMembrane ProteinsReceptors, Muscarinic

Identifiers

PMID18558434
PMCPMC2579790
OpenAlexW1983095317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.