ReviewArthritis research & therapy2008
The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
Review in Arthritis research & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks?Arthritis research & therapy · 2016Pooled it
- My treatment approach to rheumatoid arthritis.Mayo Clinic proceedings · 2012Guideline
- Existing joint erosions increase the risk of joint space narrowing independently of clinical synovitis in patients with early rheumatoid arthritis.Arthritis research & therapy · 2015Trial
- Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate.Annals of the rheumatic diseases · 2013Trial
- Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction.Annals of the rheumatic diseases · 2012Trial
- Response to rituximab and timeframe to relapse in rheumatoid arthritis patients: association with B-cell markers.Molecular diagnosis & therapy · 2010Trial
- Maintenance to target was associated with radiological outcomes in patients with rheumatoid arthritis: a real-world observational cohort study.Clinical rheumatology · 2021Observational
- Article
- Rheumatology: Necessary adjustments to the realities of the new era in Greece.Mediterranean journal of rheumatology · 2017Article
- Treatment of rheumatoid arthritis with biologics may exacerbate HTLV-1-associated conditions: A case report.Medicine · 2017Article
- Autoantibodies, C-reactive protein, erythrocyte sedimentation rate and serum cytokine profiling in monitoring of early treatment.Central-European journal of immunology · 2017Article
- Association between arthritis score at the onset of the disease and long-term locomotor outcome in adjuvant-induced arthritis in rats.Arthritis research & therapy · 2015Article
- Clinical and radiological dissociation of anti-TNF plus methotrexate treatment in early rheumatoid arthritis in routine care: results from the ABRAB study.BMC musculoskeletal disorders · 2014Observational
- Decreased circulating visfatin is associated with improved disease activity in early rheumatoid arthritis: data from the PERAC cohort.PloS one · 2014Article
- Serum levels of vasoactive intestinal peptide as a prognostic marker in early arthritis.PloS one · 2014Article
- A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.Rheumatology (Oxford, England) · 2013Article
- Baseline anti-citrullinated peptide antibody (ACPA) titers and serum interleukin-6 (IL-6) levels possibly predict progression of bone destruction in early stages of rheumatoid arthritis (ERA).Rheumatology international · 2013Article
- Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA.Nature reviews. Rheumatology · 2012Article
- Long-term stability of anti-cyclic citrullinated peptide antibody status in patients with early inflammatory polyarthritis.Arthritis research & therapy · 2012Article
- The pathogenesis of rheumatoid arthritis: new insights from old clinical data?Nature reviews. Rheumatology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various therapeutic modalities available today, especially biological agents, would provide means for optimization of care. In the present article, the current information on biological and clinical markers related to disease activity and joint damage as well as for predictive purposes is reviewed. It will be shown that the relationship of many biomarkers with disease characteristics is confounded by factors unrelated to the disease, and that only few biomarkers exist with some predictive value. Moreover, clinical markers appear of equal value as biomarkers for this purpose, although they likewise have limited capacity in these regards. The analysis suggests the search for better markers to predict outcomes and therapeutic responsiveness in rheumatoid arthritis needs to be intensified.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.