ArticleCephalalgia : an international journal of headache2008
Serotonin type 1D receptors (5HTR) are differentially distributed in nerve fibres innervating craniofacial tissues.
Article in Cephalalgia : an international journal of headache, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior.Annals of neurology · 2021Article
- From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain.Pain medicine (Malden, Mass.) · 2018Review
- Voltage-gated NaeLife · 2017Article
- Marked sexual dimorphism in 5-HTNeuroscience · 2017Article
- Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura.Cephalalgia : an international journal of headache · 2017Article
- Headache and Its Approach in Today's NeuroIntensive Care Unit.Neurocritical care · 2016Review
- Discovery of molecular markers to discriminate corneal endothelial cells in the human body.PloS one · 2015Article
- Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains.Cephalalgia : an international journal of headache · 2014Article
- Serotonin, 5HT1 agonists, and migraine: new data, but old questions still not answered.Current opinion in supportive and palliative care · 2014Review
- Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.Molecular pain · 2013Article
- Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.Neuropharmacology · 2012Article
- The complex actions of sumatriptan on rat dural afferents.Cephalalgia : an international journal of headache · 2012Article
- Sex differences in the inflammatory mediator-induced sensitization of dural afferents.Journal of neurophysiology · 2011Article
- Article
- Orofacial pain.Pain · 2011Review
- Nociceptor sensitization in pain pathogenesis.Nature medicine · 2010Article
- Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.Brain research · 2010Article
- Ionic mechanisms underlying inflammatory mediator-induced sensitization of dural afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Distribution of artemin and GFRalpha3 labeled nerve fibers in the dura mater of rat: artemin and GFRalpha3 in the dura.Headache · 2010Article
- Sumatriptan-naproxen fixed combination for acute treatment of migraine: a critical appraisal.Drug design, development and therapy · 2010Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We tested the hypothesis that the 5HT(1D)R, the primary antinociceptive target of triptans, is differentially distributed in tissues responsible for migraine pain. The density of 5HT(1D)R was quantified in tissues obtained from adult female rats with Western blot analysis. Receptor location was assessed with immunohistochemistry. The density of 5HT(1D)R was significantly greater in tissues known to produce migraine-like pain (i.e. circle of Willis and dura) than in structures in which triptans have no antinociceptive efficacy (i.e. temporalis muscle). 5HT(1D)R-like immunoreactivity was restricted to neuronal fibres, where it colocalized with calcitonin gene-related peptide and tyrosine hydroxylase immunoreactive fibres. These results are consistent with our hypothesis that the limited therapeutic profile of triptans could reflect its differential peripheral distribution and that the antinociceptive efficacy reflects inhibition of neuropeptide release from sensory afferents. An additional site of action at sympathetic efferents is also suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.