Trial reportJournal of the American Geriatrics Society2008
Long-term care facilities: a cornucopia of viral pathogens.
Trial report in Journal of the American Geriatrics Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Burden of Respiratory Syncytial Virus (RSV) Infection Among Adults in Nursing and Care Homes: A Systematic Review.Influenza and other respiratory viruses · 2024Pooled it
- A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.Nature communications · 2020Pooled it
- The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: A systematic review.PloS one · 2017Pooled it
- The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents.Croatian medical journal · 2021Trial
- Minimal Impact of Prior Common Cold Coronavirus Exposure on Immune Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination or Infection Risk in Older Adults in Congregate Care.Open forum infectious diseases · 2025Article
- Incidence of Respiratory Syncytial Virus Infection in Older Adults: Limitations of Current Data.Infectious diseases and therapy · 2023Review
- Cellular Senescence in Immunity against Infections.International journal of molecular sciences · 2022Review
- Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
- Point-of-Care Chest Ultrasonography as a Diagnostic Resource for COVID-19 Outbreak in Nursing Homes.Journal of the American Medical Directors Association · 2020Article
- A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease.medRxiv : the preprint server for health sciences · 2020Article
- Severe Respiratory Illness Outbreak Associated with Human Coronavirus NL63 in a Long-Term Care Facility.Emerging infectious diseases · 2018Article
- Bayesian evidence and epidemiological implications of environmental contamination from acute respiratory infection in long-term care facilities.Epidemiology and infection · 2018Article
- Respiratory Syncytial Virus and Other Noninfluenza Respiratory Viruses in Older Adults.Infectious disease clinics of North America · 2017Review
- Challenges and opportunities in developing respiratory syncytial virus therapeutics.The Journal of infectious diseases · 2015Article
- Therapeutic Immunoglobulin Selected for High Antibody Titer to RSV also Contains High Antibody Titers to Other Respiratory Viruses.Frontiers in immunology · 2015Article
- Other respiratory viruses are important contributors to adult respiratory hospitalizations and mortality even during peak weeks of the influenza season.Open forum infectious diseases · 2014Article
- Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.PloS one · 2014Article
- Human metapneumovirus infections on the ICU: a report of three cases.Annals of intensive care · 2012Article
- Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults.The Journal of infectious diseases · 2012Article
- Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop.The Journal of allergy and clinical immunology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period.
designObservational.
settingThirty-three Boston-area LTCFs over a 3-year period.
participantsResidents of long-term care who had previously participated in a trial of vitamin E supplementation and had paired serum samples available for viral analysis. MEASUREMENTS: Viral antibody titers to eight respiratory viruses (influenza A and B, respiratory syncytial virus (RSV), parainfluenza virus serotype three (PIV-3), PIV-2, human metapneumovirus (hMPV), and coronaviruses 229E and OC43) were measured using enzyme immunoassay at baseline and 53 weeks. Infection was defined as a more than quadrupling of viral titers. Clinical data on respiratory illnesses were collected throughout the study period.
resultsA total of 617 persons were enrolled in the trial. Of these, 382 (62%) had sera available for viral analysis. A total of 204 viral infections were documented in 157 subjects. Serological responses to all eight viruses were documented, with hMPV (12.8%) and coronavirus 229E (10.5%) being the most common and PIV-2 (2.4%) the least common. The occurrence of bronchitis (P=.007), pneumonia (P=.02), and any lower respiratory tract infection (P=.002) was significantly associated with having a viral diagnosis.
conclusionA wide range of respiratory viruses cocirculates in LTCFs and contributes to respiratory illness morbidity in these populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.